| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
Leptin (L)/amylin (A) co-administration significantly reduced food intake and body weight in leptin-resistant diet-induced obesity mice, while administration of L or A alone had no effects. L/A co-administration enhanced insulin sensitivity associated with decreased tissue triglyceride content and increased α2 AMP-activated protein kinase (AMPK) activity in skeletal muscle. This study demonstrates the beneficial effect of L/A co-administration on glucose and lipid metabolism in DIO mice, indicating the possible clinical usefulness of L/A co-administration as a new anti-diabetic treatment in obesity-associated diabetes.
|
