The Analysis of Physiological Roles of circulating ghrelin
Project/Area Number |
21790893
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Endocrinology
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Research Institution | Kyoto University |
Principal Investigator |
ARIYASU Hiroyuki Kyoto University, 医学研究科, 助教 (50378650)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 成長ホルモン / グレリン / GH(成長ホルモン) |
Research Abstract |
In this study, we generated a transgenic mouse that expresses human diphtheria toxin (DT) receptor cDNA in ghrelin-secretion cells (GPDTR-Tg mice). Administration of DT to this mouse ablates ghrelin-secretion cells in a controlled manner. Four days after injection of DT into GPDTR-Tg mice, ghrelin-secreting cells were ablated, and plasma levels of ghrelin were markedly decreased. Daily food intake of these animals, however, was not affected. Three-week-old GPDTR-Tg mice were then treated with DT twice a week for five weeks. Although plasma ghrelin levels were reduced, GPDTR-Tg mice did not display any decreases in serum GH or IGF-1 levels or any growth retardation. Our results strongly suggest that circulating ghrelin does not play a crucial role in either feeding behavior or somatic growth.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Establishment of a novel ghrelin-producing cell line.2010
Author(s)
Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology. 151
Pages: 2940-2945
Related Report
Peer Reviewed
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[Journal Article] A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth.2010
Author(s)
Ariyasu H, Iwakura H, Yamada G, Kanamoto N, Bando M, Kohno K, Sato T, Kojima M, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology. 151
Pages: 1743-1750
NAID
Related Report
Peer Reviewed
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[Journal Article] A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth.2010
Author(s)
Ariyasu H, Iwakura H, Yamada G, Kanamoto N, Bando M, Kohno K, Sato T, Kojima M, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology
Volume: 151
Pages: 1743-50
NAID
Related Report
Peer Reviewed
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[Journal Article] Establishment of a novel ghrelin-producing cell line.2010
Author(s)
Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Endocrinology
Volume: 151
Pages: 2940-45
Related Report
Peer Reviewed
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[Journal Article] A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.2009
Author(s)
Iwakura H, Ariyasu H, Li Y, Kanamoto N, Bando M, Yamada G, Hosoda H, Hosoda K, Shimatsu A, Nakao K, Kangawa K, Akamizu T.
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Journal Title
Am J Physiol Endocrinol Metab. 297
Pages: 802-811
Related Report
Peer Reviewed
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