Significance of vascular hormones in cellular metabolism and the progression of metabolic syndrome and aging
| Project/Area Number |
21790896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
MITSUISHI Masanori 慶應義塾大学, 医学部, 大学院生
MURAKI Ayako 慶應義塾大学, 医学部, 助教
TAMAKI Masanori 慶應義塾大学, 医学部, 助教
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 内分泌学 / メタボリックシンドローム / 血管ホルモン / エネルギー代謝 / ミトコンドリア / ナトリウム利尿ペプチド / cGMP依存性蛋白キナーゼ(cGK) / 細胞代謝 / 加齢 / 骨格筋 / cGMP存性蛋白キナーゼ(cGK) |
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| Research Abstract |
Recent clinical studies have indicated that dysregulation of vascular hormones would cause metabolic diseases. The present study demonstrated that natriuretic peptides and angiotensin II could modulate oxygen consumption by regulating muscle mitochondria. The findings suggest significant roles for vascular hormones as modulators of both oxygen supply and consumption, which are essential for the progression of metabolic syndrome and aging.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Natriuretic peptides/cGMP/cGMP dependent-protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity.2009
Author(s)
Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, Yamahara K, Taura D, Inuzuka M, Sonoyama T, Nakao K.
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Journal Title
Diabetes. 58
Pages: 2880-2892
Related Report
Peer Reviewed
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