Anti-MR(mineralocorticoid receptor) effect of dihydropyridine Ca channel blocker.
| Project/Area Number |
21790897
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
KURIHARA Isao 慶應義塾大学, 医学部, 講師 (90338038)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 高血圧 / アルドステロン(ミネラルコルチコイド) / ステロイドホルモン受容体 / Ca拮抗薬 / 循環器・高血圧 / ジヒドロピリジン系Ca拮抗薬 / ミネラルコルチコイド受容体 |
|---|
| Research Abstract |
The study revealed that anti-MR effect of dihydropyridine Ca channel blocker(dpCCB) can be observed in vivo(in human). We also demonstrated that dpCCB antagonized not only MR but also other steroid hormone receptors such as glucocorticoid receptor and progesterone receptor partly and in diverse manner. This finding should have great impact as a translational research in that dpCCB is one of the most commonly used antihypertensives and we demonstrated a novel beneficial aspect of this agents.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Coactivation of SF-1-Mediated Transcription of Steroidogenic Enzymes by Ubc9 and PIAS12011
Author(s)
Suda N, Shibata H, Kurihara I, Ikeda Y, Kobayashi S, Yokota K, Murai-Takeda A, Nakagawa K, Oya M, Murai M, Rainey WE, Saruta T, Itoh H
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Journal Title
Endocrinology
Volume: 152(6)
Pages: 2266-77
Related Report
Peer Reviewed
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[Journal Article] NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor2010
Author(s)
Murai-Takeda A, Shibata H, Kurihara I, Kobayashi S, Yokota K, Suda N, Mitsuishi Y, Jo R, Kitagawa H, Kato S, Saruta T, Itoh H
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Journal Title
J Biol Chem
Volume: 285(11)
Pages: 8084-93
Related Report
Peer Reviewed
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[Journal Article] Gastrointestinal pseudo-obstruction after debulking surgery of malignant pheochromocytoma, improved by intravenous administration of alpha-adrenergic receptor blocker, phentolamine2010
Author(s)
Yamaguchi S, Shibata H, Miyashita K, Kurihara I, Murai-Takeda A, Mitsuishi Y, Motosugi Y, Saito Y, Hayashi K, Itoh H
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Journal Title
Hypertens Res
Volume: 33(7)
Pages: 753-4
Related Report
Peer Reviewed
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