Mechanism of energy metabolism in white ad i pose tissue via hypothalamus and sympathetic nervous system
| Project/Area Number |
21790898
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | National Institute for Physiological Sciences |
|---|
Principal Investigator |
SHIUCHI Tetsuya National Institute for Physiological Sciences, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372729)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 白色脂肪組織 / メラノコルチン系 / 交感神経系 / 炎症性サイトカイン / βアドレナリン受容体 / 中枢神経系 / メラノコルチン受容体 |
|---|
| Research Abstract |
This study investigated effect of melanocortin receptor blockade on expression of inflammatory cytokine in white adipose tissue (WAT). Results suggest that i.c.v. administration of agouti-related protein acutely increases the proinflammatory cytokine expression such as TNF・in epididymal WAT via the attenuation of sympathetic nerve activity innervating the tissue and stimulation of beta-adrenergic receptor, without any change in the tissue hypertrophy and food intake.
|
Report
(3 results)
Research Products
(36 results)
-
[Journal Article] Decreased Intake of Sucrose Solutions in Orexin Knockout Mice.2011
Author(s)
Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T.
-
Journal Title
J Mol Neurosci. 43(2)
Pages: 217-224
Related Report
-
-
-
-
-
-
-
-
-
[Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system.2009
Author(s)
Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.
-
Journal Title
Cell Metab. 10(6)
Pages: 466-480
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
