Searching for the subcutaneous adipose tissue-derived factor that improves insulin resistance.

• Project/Area Number: 21790900
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: MIYAZAWA Takashi 独立行政法人国立循環器病研究センター, 生化学部, 客員研究員 (30443500)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内分泌 / インスリン抵抗性 / 生理活性ペプチド / 脂肪組織

Research Abstract

The metabolic syndrome, which is a recognized risk factor for cardiovascular diseases, is associated with visceral fat accumulation and insulin resistance. In this study, to identify newly endogenous factors that improve insulin resistance in liver, we developed the new assay systems and identified the insulin-like growth factor II (IGF-2) from the adipose tissues.

Research Products

• [Presentation] Identification of bioactive peptides associated with themetabolic syndrome (2010)
  • Author(s): 宮澤崇
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-03-30
• [Presentation] Identification of bioactive peptides associated with the metabolic syndrome. (2009)
  • Author(s): Miyazawa T, Miyazato M, Yoshida M, Sawai K, Mori K, Kangawa K.
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2009-03-30