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The role of Notch signaling in differentiation of human mast cells

Research Project

Project/Area Number 21790905
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionUniversity of Tsukuba

Principal Investigator

SAKATA Mamiko  University of Tsukuba, 大学院・人間総合科学研究科, 講師 (80451805)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsNotchシグナル / 臍帯血 / Delta1-Fc / Hes-1 / レトロウイルス / Notch / 肥満細胞 / ヒト臍帯血 / CD133陽性細胞 / 分化
Research Abstract

We tried to clarify the role of Notch signaling in the differentiation of human mast cells. Hematopoietic stem cells and progenitors, purified from human cord blood cells, were stimulated by plate-coated Notch ligands, or retroviral transduction of Hes-1. Notch - ligand stimulation did not induce mast cell differentiation. We succeeded in retroviral transduction of Notch signaling molecules, but the effect on differentiation of mast cells were still under the observation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (15 results)

  • [Journal Article] 慢性骨髄性白血病とHes-12011

    • Author(s)
      坂田(柳元)麻実子, 坂田麻実子
    • Journal Title

      血液フロンテイア 4月号

      Pages: 62-66

    • Related Report
      2010 Final Research Report
  • [Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.2011

    • Author(s)
      Sakata-Yanagimoto, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, chiba S
    • Journal Title

      Blood. 117(1)

      Pages: 128-134

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.2011

    • Author(s)
      Mamiko Sakata-Yanagimoto, Toru Sakai Yasuyuki Miyake, Toshiki Saito, Haruhiko Maruyama, Yasuyuki Morishita, Etsuko Nakagami-Yamaguchi, Keiki Kumano, Yagita H, Masashi Fukayama, Seishi Ogawa, Mineo Kurokawa, Koji Yasutomo, Shigeru Chiba
    • Journal Title

      Blood

      Volume: 117(1) Pages: 128-134

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性骨髄性白血病とHesl2011

    • Author(s)
      坂田-柳元麻実子, 千葉滋
    • Journal Title

      血液フロンティア

      Volume: 4月号(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.2010

    • Author(s)
      Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S
    • Journal Title

      Blood. 115(14)

      Pages: 2872-2881

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia2010

    • Author(s)
      Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Karokawa M, Kitamura T, Chiba S.
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.2009

    • Author(s)
      Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S
    • Journal Title

      Nature. 460(7257)

      Pages: 904-908

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma.2009

    • Author(s)
      Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S
    • Journal Title

      Cancer Sci. 100(5)

      Pages: 920-926

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15.2009

    • Author(s)
      Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S
    • Journal Title

      Immunol. 182(10)

      Pages: 6168-6178

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of functional mature neutrophils from human embryonic stem cells.2009

    • Author(s)
      Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi K, Takato T, Kurokawa M, Ogawa S, Chiba S
    • Journal Title

      Blood. 113(26)

      Pages: 6584-6592

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch変異と分子標的療法2009

    • Author(s)
      坂田麻実子, 坂田麻実子
    • Journal Title

      血液・腫瘍科 58(1)

      Pages: 57-62

    • Related Report
      2010 Final Research Report
  • [Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms2009

    • Author(s)
      Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto, M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
    • Journal Title

      Nature 460(7257)

      Pages: 904-908

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of functional mature neutrophils from human embryonic stem cells2009

    • Author(s)
      Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi K, Takato T, Kurokawa M, Ogawa S, Chiba S.
    • Journal Title

      Blood 113(26)

      Pages: 6584-6592

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Notch signaling as a mediator of myeloid differentiation and leukemic transformation2010

    • Author(s)
      坂田-柳元麻実子
    • Organizer
      第33回分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Notch signaling as a mediator of myeloid differentiation and leukemic transformation2010

    • Author(s)
      坂田-柳元麻実子
    • Organizer
      第5回Notch研究会
    • Place of Presentation
      野田
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Notchシグナルによる骨髄球の分化と白血病化2010

    • Author(s)
      坂田-柳元麻実子
    • Organizer
      第16回血液科学セミナー
    • Place of Presentation
      新宿
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] レトロウイルスを用いたHes-1過剰発現により不死化した骨髄前駆細胞のマイクロアレイ解析2010

    • Author(s)
      三宅康行
    • Organizer
      第72回日本血液学会学術集会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Microarray analysis of myeloid progenitors transformed via retroviral transduction of Hes-12010

    • Author(s)
      Yasuyuki Miyake
    • Organizer
      第1回JSH国際シンポジウム
    • Place of Presentation
      秋田
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Microarray analysis of myeloid progenitors immortalized via retroviral transduction of Hes-12010

    • Author(s)
      Yasuyuki Miyake
    • Organizer
      第8回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2010 Final Research Report
  • [Presentation] レトロウイルスを用いたHes-1過剰発現により不死化した骨髄前駆細胞のマイクロアレイ解析2010

    • Author(s)
      Yasuyuki Miyake, Mamiko Sakata-Yanaigmoto, Takayasu Kato, Hideharu Muto, Noriko Gotoh, Shigeru Chiba
    • Organizer
      第8回幹細胞シンポジウム
    • Place of Presentation
      淡路島
    • Related Report
      2010 Annual Research Report
  • [Presentation] Unique Gain-of-function of muatated c-CBL tumor suppressor in myeloid neoplasms2009

    • Author(s)
      Masashi Sanada
    • Organizer
      The American Society of Hematology 51^<st> Annual Meeting
    • Place of Presentation
      米国New Orleans
    • Year and Date
      2009-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Hes1 confers self-renewal capability on committed progenitors and induces CML BC-like disease2009

    • Author(s)
      Fumio Nakahara
    • Organizer
      第71回日本血液学会学術集会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Gain-of-function mutations of c-Cbl tumor suppressor in MDS and MDS/MPD associated with 11qUPD2009

    • Author(s)
      Masashi Sanada
    • Organizer
      第71回日本血液学会学術集会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Gain-of-function mutations of c-Cb1 tumor suppressor in MDS and MDS/MPD associated with 11qUPD2009

    • Author(s)
      真田昌
    • Organizer
      第71回日本血液学会学術集会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Deriviation of functional mature neutrophils from human embryonic stem cells2009

    • Author(s)
      Yasuhisa Yokoyama
    • Organizer
      第71回日本血液学会学術集会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Gain-of-function mutations of c-Cbl tumor suppressor associated with 11qUPD in myeloid neoplasms2009

    • Author(s)
      Masashi Sanada
    • Organizer
      第68回日本癌学会学術集会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Gain-of-function mutations of c-Cb1 tumor suppressor associated with 11qUPD in myeloid neoplasms2009

    • Author(s)
      真田昌
    • Organizer
      第68回日本癌学会学術集会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hes1 confers self-renewal capability on committed progenitors and induces CML BC-like disease2009

    • Author(s)
      Fumio Nakahara
    • Organizer
      第68回日本癌学会学術集会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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