| Project/Area Number |
21790921
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
FUJIWARA Shinichiro Jichi Medical University, 医学部, 助教 (20438667)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAGAI Tadashi 自治医科大学, 医学部, 准教授 (40237483)
OHMINE Ken 自治医科大学, 医学部, 講師 (90316521)
KIKUCHI Satoru 自治医科大学, 医学部, 助教
UESAWA Mitsuyo 自治医科大学, 医学部, 助教
YAMAMOTO Chihiro 自治医科大学, 医学部, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | T細胞性リンパ腫 / レトロウイルスライブラリー / RELB / RCAN1 / レトロウイルス / 癌遺伝子 |
|---|
| Research Abstract |
We constructed a retroviral cDNA expression library from lymph node of patient with T cell lymphoma. Screening of this library resulted in the identification of mutated RELB causing an amino acid substitution to impair myeloid differentiation. By gene expression analysis, RCAN1 was highly expressed in patients with myeloid leukemia. Yeast two-hybrid assay showed that RCAN1 interacted with HINT1 and RINT1, tumor suppressors. It is possible that RELB and RCAN1 are biologically significant in leukemogenesis.
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