Host defense against myelo -suppressive stress

• Project/Area Number: 21790923
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Keio University
• Principal Investigator: MIYAMOTO Kana Keio University, 医学部, 研究員 (60464997)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 血液内科学 / 破骨細胞 / 骨髄抑制 / 骨髄腔 / 造血 / 分化 / MCP-1

Research Abstract

The maintenance of haematopoietic stem cells and mobilization of haematopoietic progeniyor cells to the periphery is very important for lives. It was reported that bone marrow cavities and osteoclasts are required for maintenance of haematopoietic stem cells and mobilization of bone marrow cells to periphery, respectively. In this study, we found that bone marrow cavities and osteoclasts were both dispensable for the maintenance of haematopoietic stem cells and mobilization of bone marrow cells to p eriphery.

Research Products

• [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. (2010)
  • Author(s): Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T.
  • Journal Title: J Exp Med. 207(4) Pages: 751-762
  • Peer Reviewed
• [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner. (2009)
  • Author(s): Miyamoto K, Ninomiya K, Sonoda K, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egarashi K, Suda T, Toyama Y, Miyamoto T.
  • Journal Title: Biochem Biophys Res Commun. 383 Pages: 373-377
  • Peer Reviewed
• [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner (2009)
  • Author(s): Miyamoto K., et al.
  • Journal Title: Biochem Biophys Res Commun 383 Pages: 373-377
  • Peer Reviewed
• [Presentation] Osteoclasts as negative regulators of the hemaopoietic microenvironment. (2010)
  • Author(s): Kana Miyamoto, Yoshiaki Toyama, Takeshi Miyamoto.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Osteoclasts as negative regulators of the hemaopoietic microenvironment (2010)
  • Author(s): Kana Miyamoto, Yoshiaki Toyama, Takeshi Miyamoto
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
• [Presentation] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner. (2009)
  • Author(s): Kana Miyamoto, Takeshi Miyamoto, Toshio Suda, Yoshiaki Toyama.
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner (2009)
  • Author(s): 宮本佳奈, 他
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都