Roles of leukemia related factor MOZ and MORF in self-renewal of hematopoietic stem cells
| Project/Area Number |
21790927
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
KATSUMOTO Takuo 独立行政法人国立がん研究センター, 研究所, 研究員 (50469970)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 造血幹細胞 / 自己複製 / 転写制御因子 / ヒストンアセチル化酵素 |
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| Research Abstract |
In this study, we mainly analyzed the roles of MORF or MOZ in self-renewal of hematopoietic stem cells. High expression of MORF gene was appeared in hematopoietic stem cell fraction. Hematopoietic stem cell fractions were evenly decreased in aged and 5-FU treated MORF deficient mouse or in MOZ/MORF double heterozygous mouse. MORF was associated with AML1, PU.1 or GATA-1/2 and regulated their transcription. These results suggested MORF and MOZ modulated self-renewal activity of hematopoietic stem cells to interact with AML1, PU.1 or GATA-1/2 and to regulate their transcription activity.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] PU.1-mediated upregulation of M-CSFR is critical for MOZ-leukemia stem cell potential2010
Author(s)
Yukiko Aikawa, Takuo Katsumoto, Pu Zhang, Haruko Shima, Mika Shino, Kiminori Terui, Etsuro Ito, Hiroaki Ohno, E.Richard Stanley, Harinder Singh, Daniel G Tenen, Issay Kitabayashi
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Journal Title
Nat.Med. 16
Pages: 580-585
Related Report
Peer Reviewed
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