The identification of interacting protein with HSC specific S76 protein and analyses of hematopoietic supporting ability of S76

• Project/Area Number: 21790928
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: 財団法人東京都医学研究機構 (2010); Tokyo Metropolitan Organization for Medical Research (2009)
• Principal Investigator: MINEHATA Kenichi 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員 (50362538)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 骨髄幹細胞 / ストローマ細胞 / 造血幹細胞ニッチェ / 造血幹細胞 / ニッチェ / 骨髄 / 造血支持能

Research Abstract

We identified Calnexin and GRP78 as the interacting proteins with HSC specific S76 protein and established S76 loxP knockout mice to establish tie2-Cre/ S76 loxP mice for the analyses of hematopoietic activities in BM.