Analysis of TNFAIP3 gene function in lymphomagenesis

• Project/Area Number: 21790929
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: HONMA Keiichiro 愛知県がんセンター(研究所), 遺伝子医療研究部, 主任研究員 (20505945)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 非ホジキンリンパ腫 / NF-κB / TNFAIP3 / 悪性リンパ腫 / NF-kB

Research Abstract

Malignant lymphoma possess histologic and genetic diversity, hence understanding the mechanisms of each cases is important for improving their prognosis. In our present study, we analyzed several subsets of non-Hodgkin lymphomas and found that; (1) TNFAIP3/A20 gene is frequently altered in B-cell lymphoma with NF-kB activation. (2) TNFAIP3 may be involved in lymphomagenesis through inhibiting NF-kB. (3) Our study provides a novel insight into molecular mechanisms leading to lymphoma and that specific targeting of NF-kB pathways may be advantageous for treatment.

Research Products

• [Journal Article] Diversity of genome profiles in malignant lymphoma. (2010)
  • Author(s): Seto, M., Honma, K., Nakagawa, M.
  • Journal Title: Cancer Sci. 101 Pages: 573-578
  • NAID: 10026588848
  • Peer Reviewed
• [Journal Article] Diversity of genome profiles in malignant lymphoma. (2010)
  • Author(s): Masao Seto
  • Journal Title: Cancer Science Volume: 101 Pages: 573-578
  • Peer Reviewed
• [Journal Article] Diversity of genome profiles in malignant lymphoma. (2010)
  • Author(s): Masao Seto
  • Journal Title: Cancer Science 101 Pages: 573-578
  • Peer Reviewed
• [Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. (2009)
  • Author(s): Honma, K., Tsuzuki, S., Nakagawa, M., et al., (他4名、1番目)
  • Journal Title: Blood 114 Pages: 2467-2475
  • Peer Reviewed
• [Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of ngn-Hodgkin lymphomas. (2009)
  • Author(s): Keiichiro Honma
  • Journal Title: Blood 114 Pages: 2467-2475
  • Peer Reviewed
• [Presentation] Significant roles of TNFAIP3/A20 discovered by genome-wide array CGH analysis in B cell lymphomas (2010)
  • Author(s): 本間圭一郎
  • Organizer: 第72回日本血液学会・臨床血液学会合同総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2010-09-25
• [Presentation] Significant role of TNFAIP3/A20 discovered by genome wide array CGH in B-cell lymphoma. (2010)
  • Author(s): 本間圭一郎
  • Organizer: 第72回日本血液学会・日本臨床血液学会合同総会 ASH合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] A20 inactivation is central role of aberrant NF-kB signaling in Non-Hodgkin lymphoma. (2010)
  • Author(s): 本間圭一郎
  • Organizer: 第69回日本癌学会学術総会、International Session
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 悪性リンパ腫におけるがん抑制遺伝子TNFAIP3/A20 (2009)
  • Author(s): 本間圭一郎
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2009-10-02