Identification of molecular basis of acute-and lymphoma-type adult T-cell leukemia/lymphoma

• Project/Area Number: 21790930
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: NAKAGAWA Masao 愛知県がんセンター(研究所), 遺伝子医療研究部, 主任研究員 (80435859)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 成人T細胞性白血病 / リンパ腫 / アレイCGH / 遺伝子発現解析 / 成人T細胞性白血病リンパ腫 / マイクロアレイ

Research Abstract

Acute-type adult T-cell leukemia/lymphoma (ATLL) cases frequently have lymph node lesions. I performed detailed genomic analysis and clarified; 1) a part of such cases had genomic alterations similar to those frequently found in lymphoma-type ATLL, 2) multiple subclones with various additional genomic alterations were frequently found in a lymph node of individual cases and a selected subclone among the lymph node subclones appeared in peripheral blood. These new findings indicate that a part of acute-type ATLL cases should be categorized as lymphoma-type ATLL with leukemic change.

Research Products

• [Journal Article] Clonal evolution of adult T-cell leukemia/lymphoma takes place in lymph node. (2011)
  • Author(s): Umino, A., Nakagawa, M., et al., (他4名、2番目)
  • Journal Title: Blood In press
  • Peer Reviewed
• [Journal Article] Clonal evolution of adult T-cell leukemia/lymphoma takes place in lymph node. (2011)
  • Author(s): Akira Umino
  • Journal Title: Blood Volume: (In press)
  • Peer Reviewed
• [Journal Article] IL-4/CD40L Co-Stimulation Induces Long-Term Proliferation for CD10-Positive Germinal Center B Cell-Like Diffuse Large B-Cell Lymphoma. (2010)
  • Author(s): Kato, H., Kagami, Y., Nakagawa, M., et al., (他5名、3番目)
  • Journal Title: The Open Leukemia Journal 3 Pages: 60-68
  • Peer Reviewed
• [Journal Article] Diversity of genome profiles in malignant lymphoma. (2010)
  • Author(s): Seto, M., Honma, K., Nakagawa, M.
  • Journal Title: Cancer Sci. 101 Pages: 573-578
  • NAID: 10026588848
  • Peer Reviewed
• [Journal Article] IL-4/CD40L Co-Stimulation Induces Long-Term Proliferation for CD10-Positive Germinal Center B Cell-Like Diffuse Large B-Cell Lymphoma. (2010)
  • Author(s): Harumi Kato
  • Journal Title: The Open Leukemia Journal Volume: 3 Pages: 60-68
  • Peer Reviewed
• [Journal Article] Diversity of genome profiles in malignant lymphoma. (2010)
  • Author(s): Masao Seto
  • Journal Title: Cancer Science 101 Pages: 573-578
  • Peer Reviewed
• [Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. (2009)
  • Author(s): Honma, K., Tsuzuki, S., Nakagawa, M., et al., (他4名、3番目)
  • Journal Title: Blood 114 Pages: 2467-2475
  • Peer Reviewed
• [Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. (2009)
  • Author(s): Keiichiro Honma
  • Journal Title: Blood 114 Pages: 2467-2475
  • Peer Reviewed
• [Presentation] BCL2、c-MYC、CCND1は協調的に働き、正常B細胞をトランスフォームさせる (2010)
  • Author(s): 中川雅夫
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] アレイCGH法を用いて明らかになった急性型成人T細胞性白血病リンパ腫と末梢T細胞性リンパ腫の類似性 (2010)
  • Author(s): 海野啓
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] BCL2、c-MYC、CCND1は協調的に働き、正常B細胞をトランスフォームさせる (2010)
  • Author(s): 中川雅夫
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-09-22
• [Presentation] アレイCGH法を用いて明らかになった急性型成人T細胞性白血病リンパ腫と末梢T細胞性リンパ腫の類似性 (2010)
  • Author(s): 海野啓
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-09-22
• [Presentation] Gene expression profiling can divide Acute-type ATLL into several groups by using a specific gene set of Lymphoma-type (2009)
  • Author(s): 中川雅夫
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Gene expression profiling can divide Acute-type ATLL into several groups by using a specific gene set of Lymphoma-type (2009)
  • Author(s): 中川雅夫
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-02