| Project/Area Number |
21790935
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
KAWASAKI Aya University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (30532816)
|
|---|
| Research Collaborator |
TSUCHIYA Naoyuki 筑波大学, 大学院・人間総合科学研究科, 教授 (60231437)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 全身性エリテマトーデス / 疾患感受性遺伝子 / インターフェロン / IRF / SNP / TLR / 膠原病 / 関連研究 / 遺伝子 |
|---|
| Research Abstract |
We examined whether IRF and TLR related genes contribute to the susceptibility to systemic lupus erythematosus (SLE). Association of IRF7 and TLR7 essential for the induction of type I interferon was detected in Japanese. A single nucleotide polymorphism (SNP) located closely to IRF7 was associated with the presence of anti-Sm antibodies and renal disorder in SLE. In addition, SNPs in TLR7 3' untranslated region and intron were associated with SLE independently. Association of TNFAIP3 and TNIP1 was also observed.
|
