The role of p116Rip protein on the bronchial mucin secretion.

• Project/Area Number: 21790937
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Gunma University
• Principal Investigator: KOGA Yasuhiko Gunma University, 医学部, 医員 (10533862)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ミオシン / アクチン / p116Rip / ブレオマイシン / 間質性肺炎 / 急性肺障害 / 気道上皮 / リン酸化 / トランスジェニック マウス / ムチン

Research Abstract

We examined the effect of cell motility on the p116Rip siRNA-treated cells. Furthermore, we generated p116Rip-transgenic mice successfully and examined the effect of p116Rip protein on the Bleomycin-induced acute lung injury model mice.

Research Products

• [Journal Article] Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells. (2010)
  • Author(s): 松崎晋一
  • Journal Title: Journal of Immunology. vol.185 Pages: 4863-4872
  • Peer Reviewed
• [Journal Article] Protective effect of resolvin El on the development of asthmatic airway inflammation. (2010)
  • Author(s): 青木悠
  • Journal Title: Biochem Biophys Res Commun. vol.400 Pages: 128-133
  • Peer Reviewed
• [Journal Article] JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells. (2010)
  • Author(s): 宇津木光克
  • Journal Title: Cytokine. vol.51 Pages: 127-131
  • Peer Reviewed
• [Journal Article] Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells. (2010)
  • Author(s): 松崎晋一
  • Journal Title: Journal of Immunology Volume: 185 Pages: 4863-4872
  • Peer Reviewed
• [Journal Article] Protective effect of resolvin E1 on the development of asthmatic airway inflammation. (2010)
  • Author(s): 青木悠
  • Journal Title: Biochem Biophys Res Commun. Volume: 400 Pages: 128-133
  • Peer Reviewed
• [Journal Article] JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells. (2010)
  • Author(s): 宇津木光克
  • Journal Title: Cytokine Volume: 51 Pages: 127-131
  • Peer Reviewed
• [Presentation] 気道線維芽細胞におけるp116Ripの蛋白発現の検討 (2010)
  • Author(s): 矢富正清
  • Organizer: 第60回日本アレルギー学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-11-25
• [Presentation] 気道線維芽細胞におけるp116Ripの蛋白発現の検討 (2010)
  • Author(s): 矢富正清
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] 気道培養細胞におけるp116Ripの特異的gene silencingの検討 (2009)
  • Author(s): 古賀康彦
  • Organizer: 第59回日本アレルギー学会
  • Place of Presentation: 秋田キャッスルホテル(秋田県)
  • Year and Date: 2009-10-29
• [Presentation] 気道培養細胞におけるp116Ripの特異的 gene silencing の検討 (2009)
  • Author(s): 古賀康彦
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-29
• [Presentation] ミオシン脱リン酸化酵素を介したp116Rip proteinのミオシンリン酸化に及ぼす影響について (2009)
  • Author(s): 古賀康彦
  • Organizer: 第19回lnterAsthma
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-07-10
• [Presentation] ミオシン脱リン酸化酵素を介したp116Rip protein のミオシンリン酸化に及ぼす影響について (2009)
  • Author(s): 古賀康彦
  • Organizer: Interasma
  • Place of Presentation: 東京
  • Year and Date: 2009-07-10
• [Presentation] 気道培養細胞におけるp116Ripのタンパク質発現の検討 (2009)
  • Author(s): 古賀康彦
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-06-10
• [Presentation] 気道培養細胞におけるp116Ripのタンパク質発現の検討 (2009)
  • Author(s): 古賀康彦
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-10