Role of IL-25 in contact hypersensitivity

• Project/Area Number: 21790942
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAE Susumu The University of Tokyo, 医科学研究所, 特任准教授 (60450409)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: アレルギー学 / アレルギー / 接触型過敏症 / インターロイキン17 / インターロイキン25 / T細胞 / マスト細胞 / 皮膚炎 / サイトカイン / ノックアウトマウス

Research Abstract

We generated IL-25-deficient mice to elucidate the role of IL-25 in the pathogenesis of contact hypersensitivity. The development of contact hypersensitivity was significantly suppressed in IL-25-deficient mice, suggesting that the neutralization of IL-25 may provide a potential target for therapeutic treatment for contact hypersensitivity.

Research Products

• [Journal Article] Functional specialization of interleukin-17 family members. (2011)
  • Author(s): Iwakura, Y., Ishigame, H., Saijo, S., Nakae, S.
  • Journal Title: Immunity. 34(2) Pages: 149-162
  • Peer Reviewed
• [Journal Article] Functional specialization of interleukin-17 family members (2011)
  • Author(s): Iwakura, Y., Ishigame, H., Saijo, S., Nakae, S
  • Journal Title: Immunity Volume: 34 Pages: 149-162
  • Peer Reviewed
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • Author(s): Oboki, K., Ohno, T., Kajiwara, K., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T., Kiyonari, H., Sudo, K., Okumura, K., Saito, H., Nakae, S.
  • Journal Title: Proc Natl Acad Sci USA. 107(43) Pages: 18581-18586
  • Peer Reviewed
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. (2010)
  • Author(s): Ishii, A., Oboki, K., Nambu, A., Morita, H., Ohno, T., Kajiwara, N., Arae, K., Sudo, H., Okumura, K., Saito, H., Nakae, S.
  • Journal Title: Allergol Int. 59(4) Pages: 399-408
  • NAID: 10029671236
  • Peer Reviewed
• [Journal Article] Amphiregulin is dispensable for induction of contact hypersensitivity. (2010)
  • Author(s): Yagami, A., Kajiwara, N., Oboki, O., Ohno, N., Morita, H., Sunnarborg, S.W., Okumura, K., Ogawa, H., Saito, H., Nakae, S.
  • Journal Title: Allergol Int. 59(3) Pages: 277-284
  • Peer Reviewed
• [Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung (2010)
  • Author(s): Okamoto-Yoshida, Y., Umemura M, Yahagi, A., O'Brien, R.L., Ikuta, K., Kishihara, K., Hara, H., Nakae, S., Iwakura, Y., Matsuzaki, G
  • Journal Title: J Immunol Volume: 184 Pages: 4414-4422
  • Peer Reviewed
• [Journal Article] Altered effector CD4^+ T cell function in IL-21R^<-/-> CD4^+ T cell-mediated graft-versus-host disease. (2010)
  • Author(s): Oh, I., Ozaki, K., Meguro, A., Kadowaki, M., Matsu, H., Hatanaka, K., Tatara, R., Sato, K., Iwakura, Y., Nakae, S., Sudo, K., Teshima, T., Leonard, W.J., Ozawa, K.
  • Journal Title: J Immunol Volume: 185 Pages: 1920-1926
  • Peer Reviewed
• [Journal Article] TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in IL1rn^<-/-> mice. (2010)
  • Author(s): Nakajima, A., Matsuki, T., Komine, M., Asahina, A., Horai, R., Nakae, S., Ishigame, H., Kakuta, S., Saijo, S., Iwakura, Y
  • Journal Title: J Immunol Volume: 185 Pages: 1887-1893
  • Peer Reviewed
• [Journal Article] Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice. (2010)
  • Author(s): Kajiwara, N., Oboki, K., Ohno, T., Ishii, A., Sunnarborg, S.W., Okumura, K., Saito, H., Nakae, S.
  • Journal Title: Allergol Int. Volume: 59 Pages: 207-211
  • NAID: 10029670457
  • Peer Reviewed
• [Journal Article] Amphiregulin is dispensable for induction of contact hypersensitivity. (2010)
  • Author(s): Yagami, A., Kajiwara, N., Oboki, O., Ohno, N., Morita, H., Sunnarborg, S.W., Okumura, K., Ogawa, H., Saito, H., Nakae, S.
  • Journal Title: Allergol Int. Volume: 59 Pages: 277-284
  • Peer Reviewed
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. (2010)
  • Author(s): Ishii, A., Oboki, K., Nambu, A., Morita, H., Ohno, T., Kajiwara, N., Arae, K., Sudo, H., Okumura, K., Saito, H., Nakae, S.
  • Journal Title: Allergol Int Volume: 59 Pages: 399-408
  • NAID: 10029671236
  • Peer Reviewed
• [Journal Article] Phosphodiesterase 4B is essential for Th2 cell function and development of airway hyperresponsiveness in allergic asthma (2010)
  • Author(s): Jin, S.-L.C., Goya, S., Nakae, S., Wang, D., Bruss, M., Umetsu, D., Conti, M.
  • Journal Title: J Allergy Clin Immunol Volume: 126 Pages: 1252-1259
  • Peer Reviewed
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • Author(s): Oboki, K., Ohno, T., Kajiwara, K., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T., Kiyonari, H., Sudo, K., Okumura, K., Saito, H., Nakae, S.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107 Pages: 18581-18586
  • Peer Reviewed
• [Journal Article] IL-1 and allergy (2010)
  • Author(s): Nambu, A., Nakae, S.
  • Journal Title: Allergol Int Volume: 59 Pages: 125-135
  • NAID: 10029669907
  • Peer Reviewed
• [Journal Article] IL-33 and IL-33 receptors in host defense and diseases (2010)
  • Author(s): Oboki, K., Ohno, T., Kajiwara, N., Saito, H., Nakae, S
  • Journal Title: Allergol Int Volume: 59 Pages: 143-160
  • NAID: 10029670102
  • Peer Reviewed
• [Journal Article] IL-33-induced activation of human basophils and eosinophils via ST2. (2010)
  • Author(s): Suzukawa, M., Yamaguchi, M., Iikura, M., Koketsu, R., Komiya, A., Nagase, H., Nakae, S., Matsumoto, K., Saito, H., Matsushima, K., Yamamoto, K., Ohta, K.
  • Journal Title: Inflammation and Regeneration Volume: 30 Pages: 181-185
  • NAID: 10026385962
  • Peer Reviewed
• [Journal Article] IL-17 contributes to the development of chronic rejection in a murine heart transplant model (2010)
  • Author(s): Itoh S, Nakae S, Axtell RC, Velotta, JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP.
  • Journal Title: J Clin Immunol 30 Pages: 235-240
  • Peer Reviewed
• [Journal Article] Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction, but not the immediate-type reaction. (2009)
  • Author(s): Nishida, K., Hasegawa, A, Nakae, S., Oboki, K., Saito, H., Yamasaki, S., Hirano,T.
  • Journal Title: J Exp Med. 206(6) Pages: 1351-1364
  • Peer Reviewed
• [Journal Article] Ankylosing enthestis associated with up-regulated IFN-γ and IL-17 production in(BXSB x NZB)F1 male mice ; a new mouse model (2009)
  • Author(s): Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K, Hirose S.
  • Journal Title: Mod Rheumatol 19 Pages: 316-322
  • Peer Reviewed
• [Journal Article] A protective function for interleukin 17A in T cell-mediated intestinal inflammation (2009)
  • Author(s): O'Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA.
  • Journal Title: Nat Immunol 10 Pages: 603-609
  • Peer Reviewed
• [Journal Article] Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction, but not the immediate-type reaction (2009)
  • Author(s): Nishida K, Hasegawa A, Nakae S, Oboki K, Saito H, Yamasaki S, Hirano T.
  • Journal Title: J Exp Med 2006 Pages: 1351-1364
  • Peer Reviewed
• [Journal Article] Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse (2009)
  • Author(s): Takanashi M, Oikawa K, Sudo K, Tanaka M, Fujita K, Ishikawa A, Nakae S, Kaspar RL, Matsuzaki M, Kudo M, Kuroda M.
  • Journal Title: Gene Ther 16 Pages: 982-989
  • Peer Reviewed
• [Journal Article] T_H2 cytokines potently induce an orexigenic peptide, melanin-concentrating hormone, in human vascular endothelial cells (2009)
  • Author(s): Orihara K, Morita H, Yagami A, Kajiwara N, Nakae S, Matsumoto K, Nagasaki H, Saito Y, Saito H, Matsuda A
  • Journal Title: J Allergy Clin Immunol 124 Pages: 612-614
  • Peer Reviewed
• [Journal Article] Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses (2009)
  • Author(s): Tanaka S, Yoshimoto T, Naka T, Nakae S, Iwakura Y, Cua D, Kubo M.
  • Journal Title: J Immunol 183 Pages: 7523-7530
  • Peer Reviewed
• [Journal Article] Caspase-1, caspase-8 and calpain are dispensable for IL-33 release by macrophages (2009)
  • Author(s): Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
  • Journal Title: J Immunol 183 Pages: 7890-7897
  • Peer Reviewed
• [Presentation] アレルギーにおけるTh17細胞とマスト細胞 (2010)
  • Author(s): 中江進
  • Organizer: 日本薬学会 第130年会
  • Place of Presentation: 岡山県岡山市
  • Year and Date: 2010-03-28
• [Presentation] IL-17ファミリーとアレルギー疾患 (2010)
  • Author(s): 中江進
  • Organizer: 第6回 京都臨床アレルギー研究会
  • Place of Presentation: 京都府
  • Year and Date: 2010-03-16
• [Presentation] 非アトピー性ぜんそくモデルの作成と解析 (2009)
  • Author(s): 中江進
  • Organizer: 平成21年度(社)日本実験動物学会維持会員懇談会
  • Place of Presentation: 東京都
  • Year and Date: 2009-11-18
• [Presentation] IL-17ファミリーサイトカインとアレルギー (2009)
  • Author(s): 中江進
  • Organizer: 第12回 Forum on Allergy in Nagoya
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2009-10-10
• [Presentation] IL-17とアレルギー (2009)
  • Author(s): 中江進
  • Organizer: 第五回 箱根カンファレンス
  • Place of Presentation: 東京都
  • Year and Date: 2009-08-22
• [Presentation] 好中球性アレルギー疾患とIL-17 (2009)
  • Author(s): 中江進
  • Organizer: 第五回 自己免疫疾患研究会
  • Place of Presentation: 東京都
  • Year and Date: 2009-07-11
• [Book] Th17 cells in health and disease(ed.S.Jiang)(The roles of IL-17A and IL-17F in mucosal infection and allergy.)New York, NY (2011)
  • Author(s): Ishigame, H., Nakae, S., Iwakura, Y.
  • Publisher: Springer Science+Buisiness Media, LLC
• [Book] The roles of IL-17A and IL-17F in mucosal infection and allergy. In "Th17 cells in health and disease", (ed.S.Jiang). (2011)
  • Author(s): Ishigame, H., Nakae, S., Iwakura, Y.
  • Publisher: Springer Science + Buisiness Media, LLC, New York, NY(刊行確定)(in press)
• [Book] 「4.粘膜における自然免疫、b.肥満細胞・好酸球・好塩基球」臨床粘膜免疫学、清野宏・編 (2010)
  • Author(s): 斎藤博久、大保木啓介、中江進、烏山一
  • Publisher: 株式会社シナジー
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/frontier/index.html