| Project/Area Number |
21790949
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nagasaki University |
|---|
Principal Investigator |
YAMASAKI Satoshi Nagasaki University, 医歯(薬)学総合研究科, 助教 (30367388)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 関節リウマチ / 滑膜細胞 / 脂肪分化 / RNA regulon / iPS |
|---|
| Research Abstract |
Adipogenesis is clearly inhibited by various inflammatory cytokines in both MSC and FLS. The production of IL-6 is inhibited after adipogenesis in both MSC and FLS. Adipogenesis of MSC disrupt the actin structure, which leads to the less migration ability of the cell. Our results indicate that undifferentiated and proliferating MSC in "bone edema", a recently recognized as inflammatory bone marrow lesion in early stage of rheumatoid arthritis, contribute to the progression of the disease, therefore, the adipogenic induction of MSC and FLS can regenerate a favorable joint environment for maintaining auricular structure.
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