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The role of inflammatory cells in the process of fibrosis

Research Project

Project/Area Number 21790951
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKeio University

Principal Investigator

YASUOKA Hidekata  Keio University, 医学部, 助教 (60365260)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords線維化 / 炎症 / 単球 / 膠原病 / 肺線維症 / 強皮症
Research Abstract

The aim of this study is to clarify the role of inflammatory cells in the process of fibrosis. We focused on monocytes, then we first examined the phenotype of circulating monocytes in systemic sclerosis (SSc), which is a prototype of fibrotic disease. In SSc monocytes, expression of versican, one of extracellular matrix components was upregulated. Versican was bound to MCP-1, and the versican-MCP-1 complex induced migration of monocytes effectively. Thus, versican serves as a reservoir of chemokine such as MCP-1 and migration of monocyte is induced via concentration gradient of MCP-1. Thus, migrated monocyte may be involved in the process of fibrosis. We then examined the role of monocytes infiltrated into the tissue, using a mouse model which induced massive migration of monocytes into tissues. We found that this mouse could induce deposition of extracellular matices especially surrounding of infiltrating monocytes. These results suggest that monocytes play and important role in the process of fibrosis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Decreased caveolin-1 levels contribute to fibrosis and deposition of extra cellular IGFBP-5.2010

    • Author(s)
      Yamaguchi Y, Yasuoka H, et al
    • Journal Title

      J Cell Mol Med

      Volume: (online)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Upregulated expression of versican in monocytes from patients with systemic sclerosis : role in amplification of monocytes-chemoatrractant protein-1 (MCP-1) activity at site of fibrosis.2010

    • Author(s)
      Yasuoka H., et al.
    • Organizer
      1^<st> Systemic Sclerosis World Congress.
    • Place of Presentation
      Florence, Italy.
    • Year and Date
      2010-02-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Upregulated expression of versican in monocytes from patients with systemic sclerosis : role in amplification of monocytes-chemoatrractant protein-1 (MCP-1) activity at site of fibrosis.2010

    • Author(s)
      Yasuoka H., et al.
    • Organizer
      1^<st> Systemic Sclerosis World Congress
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Upregulated versican in monocytes from patients with systemic sclerosis : Role in Amplification of monocytechemoattractant protein-1 (MCP-1) activity at site of fibrosis.2009

    • Author(s)
      Yasuoka H., et al.
    • Organizer
      Annual Scientific Meeting of American College of Rheumatology.
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2009-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Upregulated versican in monocytes from patients with systemic sclerosis : Role in Amplification of monocytes-chemoattractant protein-1 (MCP-1) activity at site of fibrosis.2009

    • Author(s)
      Yasuoka H., et al.
    • Organizer
      Annual Scientific Meeting of American College of Rheumatology.
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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