Discovery of genes associated with atopic dermatitis
| Project/Area Number |
21790954
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HIROTA Tomomitsu The Institute of Physical and Chemical Research, 呼吸器疾患研究チーム, リサーチアソシエイト (50435674)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アトピー性皮膚炎 / 遺伝子多型 / 遺伝学 / 疾患関連遺伝子 |
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| Research Abstract |
CCL22 gene plays an important role in atopic dermatitis (AD). We surveyed genetic variations and conducted association studies of the gene in two independent Japanese populations. We observed a strong association between a CCL22 SNP and AD (P=.0000089, combined by the Mantel-Haenszel meta-analysis ; OR, 1.35 ; 95% CI, 1.18-1.54). The susceptible allele showed higher mRNA expression in ASTQ analysis. The polymorphism of the CCL22 gene might be involved in atopic dermatitis in a gain of function manner.
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Report
(3 results)
Research Products
(34 results)
