Discovery of genes associated with atopic dermatitis

• Project/Area Number: 21790954
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: HIROTA Tomomitsu The Institute of Physical and Chemical Research, 呼吸器疾患研究チーム, リサーチアソシエイト (50435674)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アトピー性皮膚炎 / 遺伝子多型 / 遺伝学 / 疾患関連遺伝子

Research Abstract

CCL22 gene plays an important role in atopic dermatitis (AD). We surveyed genetic variations and conducted association studies of the gene in two independent Japanese populations. We observed a strong association between a CCL22 SNP and AD (P=.0000089, combined by the Mantel-Haenszel meta-analysis ; OR, 1.35 ; 95% CI, 1.18-1.54). The susceptible allele showed higher mRNA expression in ASTQ analysis. The polymorphism of the CCL22 gene might be involved in atopic dermatitis in a gain of function manner.

Research Products

• [Journal Article] S2554X mutation in the filaggrin gene is associated with allergen sensitization in the Japanese population. (2010)
  • Author(s): Imoto Y, Hirota T, Noguchi E, et al, 8番目/12人
  • Journal Title: J Allergy Clin Immunol. 125 Pages: 498-500
  • Peer Reviewed
• [Journal Article] A functional polymorphism (-603A-> G) in the tissue factor gene promoter is associated with adult-onset asthma. (2010)
  • Author(s): Isada A, Konno S, Hirota T, et al, 5番目/10人
  • Journal Title: J Hum Genet. 55 Pages: 167-174
  • NAID: 10030734031
  • Peer Reviewed
• [Journal Article] Prevalence of Allergic Rhinitis and Sensitization to Common Aeroallergens in a Japanese Population. (2010)
  • Author(s): Sakashita M, Hirota T, Harada M, et al, 2番目/14人
  • Journal Title: Int Arch Allergy Immunol. 151 Pages: 255-261
  • Peer Reviewed
• [Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma. (2010)
  • Author(s): Harada M, Hirota T, Tamari M., et al, 2番目/33人
  • Journal Title: Am J Respir Cell Mol Biol(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Replication of genetic association studies in asthma and related phenotypes. (2010)
  • Author(s): Undarmaa S, Hirota T, Suzuki Y, et al, 10番目/13人
  • Journal Title: 55 Pages: 342-349
  • NAID: 10030735318
  • Peer Reviewed
• [Journal Article] 基礎医学とのダイアローグSNP解析を用いた稀少疾患の解明 (2010)
  • Author(s): 広田朝光, 玉利真由美, 1番目/2人
  • Journal Title: THE Lung perspectives 18(2) Pages: 52-56
• [Journal Article] 特集:アレルギー疾患に対するオーダーメイド医療I.アレルギー疾患の遺伝子と遺伝学 (2010)
  • Author(s): 広田朝光, 冨田かおり, 玉利真由美, 1番目/3人
  • Journal Title: アレルギー・免疫 17(10) Pages: 1652-1660
• [Journal Article] 綜説薬剤の効果と遺伝要因 (2010)
  • Author(s): 広田朝光, 冨田かおり, 玉利真由美, 1番目/3人
  • Journal Title: 呼吸と循環 59(6) Pages: 597-604
• [Journal Article] Replication of genetic association studies in asthma and related phenotypes. (2010)
  • Author(s): Undarmaa S, Hirota T, et al
  • Journal Title: Journal of Human Genetics Volume: 55 Pages: 342-349
  • NAID: 10030735318
  • Peer Reviewed
• [Journal Article] アレルギー疾患と遺伝子多型 (2010)
  • Author(s): 広田朝光
  • Journal Title: 小児科臨床 Volume: 63 Pages: 2409-2416
• [Journal Article] S2554X mutation in the filaggrin gene is associated with allergen sensitization in the Japanese population (2010)
  • Author(s): Yoshimasa Imoto
  • Journal Title: Journal of Allergy and Clinical Immunology 125 Pages: 498-500
  • Peer Reviewed
• [Journal Article] Prevalence of Allergic Rhinitis and Sensitization to Common Aeroallergens in a Japanese Population (2010)
  • Author(s): Sakashita Masafumi
  • Journal Title: International Archives of Allergy and Immunology 151 Pages: 255-261
  • Peer Reviewed
• [Journal Article] Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin -induced asthma. (2009)
  • Author(s): Hitomi Y, Hirota T, Tamari M., et al, 6番目/19人
  • Journal Title: J Allergy Clin Immunol. 124 Pages: 779-785
  • Peer Reviewed
• [Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma. (2009)
  • Author(s): Harada M, Obara K, Hirota T, et al, 3番目/16人
  • Journal Title: Am J Respir Crit Care Med. 180 Pages: 1048-1055
  • Peer Reviewed
• [Journal Article] Associations between decay- accelerating factor polymorphisms and allergic respiratory diseases. (2009)
  • Author(s): Kawai T, Hirota T, Noguchi E, et al, 9番目/12人
  • Journal Title: Clin Exp Allergy. 39 Pages: 1508-1514
  • Peer Reviewed
• [Journal Article] SMAD3 as an atopic dermatitis susceptibility gene in the Japanese population. (2009)
  • Author(s): Otsuka K, Hirota T, Noguchi E, et al, 5番目/11人
  • Journal Title: J Dermatol Sci. 55 Pages: 200-202
  • NAID: 10029371898
  • Peer Reviewed
• [Journal Article] Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma (2009)
  • Author(s): Yuki Hitomi
  • Journal Title: Journal of Allergy and Clinical Immunology 124 Pages: 799-785
  • Peer Reviewed
• [Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma (2009)
  • Author(s): Michishige Harada
  • Journal Title: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180 Pages: 1048-1055
  • Peer Reviewed
• [Journal Article] Associations between decay-accelerating factor polymorphisms and allergic respiratory diseases (2009)
  • Author(s): Kawai T
  • Journal Title: Clinical & Experimental Allergy 39 Pages: 1508-1514
  • Peer Reviewed
• [Journal Article] SMAD3 as an atopic dermatitis susceptibility gene in the Japanese population (2009)
  • Author(s): Kenta Otsuka
  • Journal Title: Journal of Dermatological Science 55 Pages: 200-202
  • Peer Reviewed
• [Journal Article] 日本人における気管支喘息関連遺伝子 (2009)
  • Author(s): 広田朝光
  • Journal Title: 呼吸 28 Pages: 603-608
• [Journal Article] 小児呼吸器疾患とゲノム解析 (2009)
  • Author(s): 広田朝光
  • Journal Title: 小児科 50 Pages: 861-865
• [Journal Article] 小児アレルギー疾患の治療・管理の新しい展開I.基礎研究の進歩2.アレルギー疾患と遺伝子多型
  • Author(s): 広田朝光, 冨田かおり, 玉利真由美, 1番目/3人
  • Journal Title: 小児科臨床 63(12) Pages: 2409-2415
• [Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma.
  • Author(s): Harada M, Hirota T, et al
  • Journal Title: American Journal of Respiratory Cell and Molecular Biology Volume: (In press)
  • Peer Reviewed
• [Journal Article] A functional polymorphism(-603A-->G)in the tissue factor gene promoter is associated with adult-onset asthma
  • Author(s): Akira Isada
  • Journal Title: Journal of Human Genetics (In press)
  • Peer Reviewed
• [Presentation] CCL22遺伝子多型とアトピー性皮膚炎の関連解析MW6-3 (2010)
  • Author(s): 広田朝光
  • Organizer: 第60回日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] CCL22遺伝子多型とアトピー性皮膚炎の関連解析 (2010)
  • Author(s): 広田朝光
  • Organizer: 第60回日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] CCL22遺伝子多型とアトピー性皮膚炎の関連解析OP4-19 (2010)
  • Author(s): 広田朝光
  • Organizer: 第55回日本人類遺伝学会
  • Place of Presentation: 大宮
  • Year and Date: 2010-10-28
• [Presentation] CCL22遺伝子多型とアトピー性皮膚炎の関連解析 (2010)
  • Author(s): 広田朝光
  • Organizer: 第55回日本人類遺伝学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-28
• [Presentation] 日本人集団におけるアトピー性皮膚炎と乾癬のGWASの検証 (2009)
  • Author(s): 広田朝光
  • Organizer: 日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田市
  • Year and Date: 2009-10-29
• [Presentation] 17q21 locusの遺伝子多型とスギ花粉症の相関解析PA055 (2009)
  • Author(s): 広田朝光
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-24
• [Presentation] 日本人集団におけるアトピー性皮膚炎と乾癬のGWASの検証MS-21-16 (2009)
  • Author(s): 広田朝光
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-09-24
• [Presentation] 17q21 locus の遺伝子多型とスギ花粉症の相関解析 (2009)
  • Author(s): 広田朝光
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-24
• [Remarks] ホームページ等