| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We analyzed using monoclonal antibodies for neutralizing HBV, which were obtained by cell-microarray system. Epitope analysis showed that extracellular loop lesion of HBs-Ag has the antigenesity and concerns HBV-neutralization. Combination of the antibodies showed the neutralizing capacity against various genotype of HBV including G145R which is known for the escape mutant. These findings imply that HBV-vaccination is useful for the prevention of HBV-infection with various genotype or mutant HBV. Furthermore, the possibilities of antibody treatment using monoclonal antibodies or their combination for HBV-infection may be suggested.
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