| Project/Area Number |
21790962
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 感染症防御学 / 多剤耐性緑膿菌(MDRP) / 院内感染対策 / 抗菌薬適正使用 / 耐性化機序 / 接触感染対策 / 抗菌薬選択圧 / 2剤耐性緑膿菌 / メタロβラクタマーゼ(MBL) / 水平伝播 / 抗菌薬併用療法 / BC-plate法 |
|---|
| Research Abstract |
Infection control for MDRP was initiated based on the mechanism of multidrug-resistance. Amelioration of the urine-collecting systems and intervention for proper usage of the carbapenem antibiotics were performed, then consumption of antibiotics and isolation rate of antibiotic resistant Pseudomonas aeruginosa were significantly reduced. From the genomic research, our results indicated the diversity of MDRP, possible co-existence of different clones and same clones in a patient, spreading in a ward and in a hospital.
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