Analysis of the pathogenesis of the IgA nephropathy by the interaction of the innate and acquired immunity in post-viral infection
Project/Area Number |
21790964
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Infectious disease medicine
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Research Institution | Fukuoka University |
Principal Investigator |
MIYAKE Katsuhisa Fukuoka University, 医学部, 講師 (50448411)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 自然免疫 / 獲得免疫 / IgA腎症 |
Research Abstract |
IgA nephropathy (IgAN) in early stage is an asymptomatic kidney disease detected by chance proteinuria and/or hematuria. In this study, we analyzed mRNA expressions of toll like receptors (TLRs) and inflammatory cytokines in the renal biopsy tissues from IgAN in early stage, ANCA-related nephritis and membranous nephropathy patients. As a result the expressions of transcripts for TLR9 and IFNα in IgAN in early stage were significantly higher than those for others. These results suggested that the innate immunity may play a central role for development of IgAN in the early stage. Therefore TLR 9 signal and IFNα will be new candidates for new treatment for IgAN.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium.2009
Author(s)
Watanabe M, Nakashima H, Mochizuki S, Abe Y, Ishimura A, Ito K, Fukushima T, Miyake K, Ogahara S, Saito T.
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Journal Title
Am J Nephrol. (1)
Pages: 1-11
Related Report
Peer Reviewed
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[Journal Article] The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.2009
Author(s)
Kurabe N, Arai S, Nishijima A, Kubota N, Suizu F, Mori M, Kurokawa J, Kondo-Miyazaki M, Ide T, Murakami K, Miyake K, Ueki K, Koga H, Yatomi Y, Tashiro F, Noguchi M, Kadowaki T, Miyazaki T.
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Journal Title
J Biol Chem. 284(8)
Pages: 5050-5055
Related Report
Peer Reviewed
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