Development of biomarkers for the elucidation of pathophysiology and early diagnosis of chronic allograft nephropathy
| Project/Area Number |
21790971
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 慢性移植腎症 / マクロファージ / CD163抗原 / 間質線維化 |
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| Research Abstract |
Chronic allograft nephropathy(CAN) is the major cause of failure of renal graft function. It has posed diagnostic challenge and there have been no non-invasive diagnostic procedures of CAN that is also safe for pediatric patients.
We have previously reported that activated macrophages(Mφ) play a major role in renal tissue impairment and fibrosis and shown that CD163-positive Mφ, one of Mφsubtypes, may be involved in the formation of chronic lesions.
In this study, we measured urinary CD163 antigen levels and investigated their correlation with histological and clinical findings. In renal biopsy specimens, the number of interstitial CD163-positive Mφwas positively correlated with severity of fibrosis. The urinary CD163 levels were also correlated with renal graft function in the stable phase after the acute phase and may indicate the degree of progression of renal graft fibrosis.
These results suggest that CD163-positive Mφis deeply involved in the progression of CAN and the urinary CD163 can be used as a non-invasive marker for the early diagnosis of CAN.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Nonadherenceを原因とする拒絶反応から、移植腎機能低下をきたした13歳男児例思春期における腎移植後患児のNonadherenceについて2012
Author(s)
鈴木俊明, 池住洋平, 唐澤環, 長谷川博也, 内山聖, 中川由希, 斎藤和英, 高橋公太, 石原俊二, 原正則, 柳原俊雄
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Journal Title
日本小児腎臓病学会雑誌
Volume: 25
Pages: 58-62
Related Report
Peer Reviewed
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[Journal Article] Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy : potential role in mesangial matrix expansion2011
Author(s)
Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Yamada T, Imai N, Narita I, Kawachi H, Polkinghorne KR, Nikolic-Paterson DJ, Uchiyama M
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Journal Title
Histopathology
Volume: 58
Pages: 198-210
Related Report
Peer Reviewed
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