Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Research Abstract |
Inter leukin-18(IL-18), found as interferon-γinducing factor, plays a critical role in innate and acquired immune response against microbes. IL-18 would also contribute to the pathogenesis of inflammatory diseases. To elucidate the pathogenesis and structure of IL-18 I igand-receptor complex, we have expressed recombinant IL-18Rαand IL-18Rβwith baculo-Insect cell systems and crystallized it as IL-18/IL18Rα/IL-18Rβheterotr imer ic complex and obtained X-ray diffraction data from the crystal.
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