Study on generation of skeletal muscle stem/progenitor cells from human induced pluripotent stem cell.

• Project/Area Number: 21790984
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Kyoto University
• Principal Investigator: KATO Takeo Kyoto University, 医学研究科, 助教 (60422945)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: iPS細胞 / 骨格筋分化誘導 / 骨格筋前駆細胞

Research Abstract

We developed an efficient system for the generation of skeletal muscle stem/progenitor cells from human ES cells and human iPS cells.

Research Products

• [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent cells. (2010)
  • Author(s): Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukada SI, Yamamoto H, Yamanaka S, Nakahata T, Heike T.
  • Journal Title: FASEB J.
• [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent cells. (2010)
  • Author(s): Mizuno Y, Awaya T, Heike T.
  • Journal Title: FASEB J. Volume: 24 Pages: 2245-2253
  • Peer Reviewed
• [Presentation] 筋ジストロフィーに対する治療研究の進歩「iPS細胞を用いた筋ジストロフィーの再生移植治療」 (2011)
  • Author(s): 平家俊男
  • Organizer: 平成22年度精神・神経疾患研究委託費「筋ジストロフィー研究」合同班会議
  • Place of Presentation: 東京
  • Year and Date: 2011-01-07
• [Presentation] 多能性幹細胞(ES細胞、iPS細胞)を用いた骨格筋幹/前駆細胞の同定およびその臨床応用に関する研究 (2010)
  • Author(s): 粟屋智就、加藤竹雄、平家俊男
  • Organizer: 平成22年度精神・神経疾患研究委託費「筋ジストロフィーに対するトランスレーショナル・リサーチ」(武田班)班会議
  • Place of Presentation: 東京
  • Year and Date: 2010-12-13
• [Presentation] 多能性幹細胞(ES細胞、iPS細胞)を用いた骨格筋幹/前駆細胞の同定およびその臨床応用に関する研究 (2009)
  • Author(s): 粟屋智就、水野雄太、張璽、加藤竹雄、丹羽明、中畑龍俊、平家俊男
  • Organizer: 平成21年度厚生労働省精神・神経疾患研究委託費「筋ジストロフィーに対する治療研究を臨床に応用するための統括的研究」(武田班)班会議
  • Place of Presentation: 東京
  • Year and Date: 2009-12-03
• [Presentation] Derivation of engraftable muscle precursors from murine ES/iPS cells. The 8th French-Japanese Workshop on Muscular Dystrophy. (2009)
  • Author(s): Awaya T, Chang H, Mizuno Y, Niwa A, Iwasa T, Umeda K, Fukada SI, Yamamoto H, Motohashi N, Suzuki Y, Takeda S, Yamanaka S, Nakahata T, Heike T.
  • Organizer: New developments of therapeutic strategy for muscular dystrophies
  • Place of Presentation: Paris