Association between innate immunity and pathophysiology of Kawasaki disease

• Project/Area Number: 21790993
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: 池田 和幸 Kyushu University, 医学研究院・成長発達医学分野, 九州大学病院小児科講師 (30507786)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 川崎病 / 自然免疫

Research Abstract

Both microarray and quantitative RT-PCR analyses have shown that the innate immune system might be involved in the pathogenesis and pathophysiology of Kawasaki disease. NOD Ligands enhance ICAM-1 expression and cytokine production by human coronary artery endothelial cells in vitro.

Research Products

• [Journal Article] Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease. (2010)
  • Author(s): Ikeda K, Yamaguchi K, Tanaka T, Mizuno Y, Hijikata A, Ohara O, Takada H, Kusuhara K, Hara T
  • Journal Title: Clin Exp Immunol 160 Pages: 246-55
• [Journal Article] Incomplete Kawasaki disease in a patient with chronic granulomatous disease. (2010)
  • Author(s): Muneuchi J, Ishimura M, Takada H, Hoshina T, Utsunomiya R, Ikeda K, Yamaguchi K, Ohga S, Kusuhara K, Hara T
  • Journal Title: Pediatr Int 52 Pages: 134-136
• [Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na(v)1.5 in a neonate with fatal long QT syndrome. (2010)
  • Author(s): Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane Y, Makiyama T, Horie M, Hara T
  • Journal Title: Int J Cardiol 145 Pages: 61-64
• [Journal Article] Unique activation status of peripheral blood mononuclear cells at a cute phase of Kawasaki disease. (2010)
  • Author(s): Kazuyuki Ikeda
  • Journal Title: Clin Exp Immunol Volume: 160 Pages: 246-55
  • Peer Reviewed
• [Journal Article] Unique activation status of peripheral blood mononuclear cells at acute phase of kawasaki disease.
  • Author(s): Kazuyuki Ikeda
  • Journal Title: Clin Exp Immunol (In press)
  • Peer Reviewed
• [Presentation] Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease. (2010)
  • Author(s): Ikeda K, Yamaguchi K, Tanaka T, Mizuno Y, Hijikata A, Ohara O, Takada H, Kusuhara K, Hara T
  • Organizer: The Fukuoka International Symposium on Perinatal Medicine (FISPM).
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2010-08-21
• [Presentation] 原寿郎Host genetic factor と臨床データを組み合わせた新たな冠動脈病変(CAL)予測法の開発 (2010)
  • Author(s): 池田和幸、山村健一郎、永田弾、松尾知子、水野由美
  • Organizer: 第9回九州川崎病研究会
  • Place of Presentation: 長崎
  • Year and Date: 2010-05-22
• [Presentation] Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease. (2010)
  • Author(s): Ikeda K, Yamaguchi K, Tanaka T, Mizuno Y, Hijikata A, Ohara O, Takada H, Kusuhara K, Hara T
  • Organizer: The 6th Congress of Asian Society of Pediatric Research.
  • Place of Presentation: Taipei, Taiwan
• [Presentation] 原寿郎重度細胞性免疫不全症のため動脈管ステント留置術を選択した総動脈管症、大動脈弓離断症の1例 (2010)
  • Author(s): 池田和幸、山村健一郎、井上普介、宗内淳、永田弾、総崎直樹、角秀秋
  • Organizer: 第21回日本 Pediatric InterventionalCardiology研究会
  • Place of Presentation: 静岡
• [Presentation] 原寿郎Host genetic factor と臨床データを組み合わせた新たな冠動脈病変(CAL)予測法の開発 (2010)
  • Author(s): 池田和幸、山村健一郎、永田弾、松尾知子、水野由美
  • Organizer: 第46回日本小児循環器学会総会・学術集会
  • Place of Presentation: 千葉
• [Presentation] 原寿郎遺伝子多型解析を用いた川崎病発症に関する宿主因子の検討 (2010)
  • Author(s): 池田和幸、山村健一郎、永田弾、松尾知子、水野由美
  • Organizer: 第30回日本川崎病学会
  • Place of Presentation: 京都
• [Presentation] Host genetic factorと臨床データを組み合わせた新たな冠動脈病変(CAL)予測法の開発 (2010)
  • Author(s): 池田和幸, 他
  • Organizer: 第46回日本小児循環器学会総会・学術集会
  • Place of Presentation: 千葉
• [Presentation] 川崎病の包括的研究1 急性期病態と自然免疫の関連 (2009)
  • Author(s): 池田和幸
  • Organizer: 日本小児科学会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2009-04-18