Monitoring cytokine expressions prior to relapse in patients with pediatric acute lymphoblastic leukemia

Research Project

Project/Area Number	21790997
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Pediatrics
Research Institution	Kyushu University
Principal Investigator	KOGA Yuhki 九州大学, 大学病院, 助教 (60398071)
Project Period (FY)	2009 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	小児がん / 白血病 / 分子遺伝学 / 小児科学 / 小児白血病 / マイクアレイ / サイトカイン
Research Abstract	We analyzed the cytokine expression pattern in relapsed childhood leukemia. By serumcytokine expression analysis of relapse and non-relapse cases, we found that inflammatorycytokines TNF, IL-6 in relapse cases are significantly higher than in non-relapse cases. In relapse cases, inflammatory cytokines was decreased at the time of remission, and increased at the time of relapse. Inflammatory cytokine levels of childhood leukemia at the initial diagnosis may predict their prognosis of leukemia.