IL-17E signaling regulates podocyte function and proteinuria

Research Project

Project/Area Number	21790998
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Pediatrics
Research Institution	University of Miyazaki
Principal Investigator	KONOMOTO Takao University of Miyazaki, 医学部, 助教 (80315366)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	ポドサイト / インターロイキン17E / シグナル伝達 / IL17E(IL25)
Research Abstract	IL-17E, a member of the IL-17 cytokine families, is known associate with allergic diseases. The roles of IL-17E are unknown in renal diseases. The aims of study are to investigate the effect of IL-17E on podocyte injuries. IL-17RB, a major receptor of IL-17E was expressed on human podocyte cell line. Our result showed that phosphorylation of ERK was increased and phosphorylation of p38MAPK transiently redused in the IL-17E treated podocyte. And the nephrin mRNA expression was up-regulated. Il-17E changed nephrin mRNA expression via ERK and p38MAPK signaling.

Report

(3 results)