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Exploration of disease-specific biomarker in systemic juvenile idiopathic arthritis.

Research Project

Project/Area Number 21791002
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

AOYAMA Michiko  Kyoto Prefectural University of Medicine, 医学研究科, 助教 (40363981)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords全身型若年性特発性関節炎 / プロテオミクス / ネイティブPAGE / 臨床プロテオミクス / バイオマーカー探索 / 若年性特発性関節炎
Research Abstract

Diagnostic biomarker in systemic juvenile arthritis (sJIA) remains to be elucidated. An exploration of disease-specific marker in sJIA was conducted with a native PAGE-combined 2-DE. Peptide mapping with sera form 4 sJIA patients revealed several spots such as iron-related proteins, lipoproteins, complements, globulin-related molecules, which were similar in profiling pattern to the control samples from febrile patients. Haptoglobin 2-2 genotype was uniformaly detected in sJIA sera. A unique transthyretin-combined protein complex was also profiled in sJIA sera. These results might be a breakthrough in establishing sJIA-specific biomarker.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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