| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Irradiation and high-dose chemotherapy followed by bone marrow transplantation (BMT) have been a routine treatment for hematological malignancies and solid tumors. These conditioning, however, should be minimized since the toxicity extends to all organs generating serious side effects. In the adult BM, HSCs interact with its microenvironment which supports the activity of HSCs to maintain quiescence or self-renew to provide blood cells throughout the lifetime of an individual. This particular microenvironment, called stem cell niche, is critical for the maintenance of HSCs. In this study, we manipulated the niche for efficient engraftment avoiding redundant side effects of conditionings. We found that AMM2 or interferon-alpha is a promising niche regulator for transplantation without irradiation or high dose chemotherapy. Achievement of non-irradiated BMT method will provide advancement in stem cell therapy overcoming serious side effects.
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