Tissue-specific roles of inositol 1,4,5-trisphosphate receptors for cardiovascular development

• Project/Area Number: 21791004
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Keio University
• Principal Investigator: UCHIDA Keiko Keio University, 医学部, 共同研究員 (50286522)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 発生 / 循環器 / シグナル伝達 / 発生・分化 / 再生医学 / 循環器・高血圧 / 動物

Research Abstract

We previously showed that inositol 1, 4, 5-trisphosphate receptor (IP3R) 1 and 3 double knockout (1/3DKO) mice exhibited the defect of cardiovascular development. Our results from the marker analyses and the generation of tissue-specific 1/3DKO mice suggested that IP3R1 and 3 do not function in the subpopulation of the second heart field originated from Tbx1 expressed cells during heart development, and that IP3R1 and 3 in the endothelial cells may play redundant roles for the angiogenesis during embryonic vascular development.

Research Products

• [Journal Article] Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field. (2011)
  • Author(s): Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H.
  • Journal Title: Journal of Molecular and Cellular Cardiology (in press).
  • Peer Reviewed
• [Journal Article] Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. (2010)
  • Author(s): Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H.
  • Journal Title: PloS ONE 5
  • Peer Reviewed
• [Journal Article] Gene Knock-outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis (2010)
  • Author(s): 内田敬子
  • Journal Title: PLoS One Volume: Vol.5
  • Peer Reviewed
• [Journal Article] Molecular embryology for an understanding of congenital heart diseases. (2009)
  • Author(s): Yamagishi H, Maeda J, Uchida K, Tsuchihashi T, Nakazawa M, Aramaki M, Kodo K, Yamagishi C.
  • Journal Title: Anatomical Science International 84 Pages: 88-94
  • NAID: 10025550383
  • Peer Reviewed
• [Presentation] Type 1 and 3 Inositol 1,4,5-Trisphosphate Receptors in the Endotheliumare Required for Angiogenesis during Embryonic Vascular Development (2010)
  • Author(s): 内田敬子
  • Organizer: アメリカ心臓学会
  • Place of Presentation: マコーミックプレイス(米国、シカゴ)
  • Year and Date: 2010-11-16
• [Presentation] Type 1 and 3 Inositol 1,4,5-Trisphosphate Receptors in the Endothelium are Required for Angiogenesis during Embryonic Vascular Development (2010)
  • Author(s): 内田敬子
  • Organizer: アメリカ心臓学会
  • Place of Presentation: マコーミックプレイス(シカゴ)
  • Year and Date: 2010-11-16
• [Remarks] ホームページ等 なし