Tissue-specific roles of inositol 1,4,5-trisphosphate receptors for cardiovascular development
| Project/Area Number |
21791004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Keio University |
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Principal Investigator |
UCHIDA Keiko Keio University, 医学部, 共同研究員 (50286522)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 発生 / 循環器 / シグナル伝達 / 発生・分化 / 再生医学 / 循環器・高血圧 / 動物 |
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| Research Abstract |
We previously showed that inositol 1, 4, 5-trisphosphate receptor (IP3R) 1 and 3 double knockout (1/3DKO) mice exhibited the defect of cardiovascular development. Our results from the marker analyses and the generation of tissue-specific 1/3DKO mice suggested that IP3R1 and 3 do not function in the subpopulation of the second heart field originated from Tbx1 expressed cells during heart development, and that IP3R1 and 3 in the endothelial cells may play redundant roles for the angiogenesis during embryonic vascular development.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.2010
Author(s)
Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H.
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Journal Title
Related Report
Peer Reviewed
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