Leukemic stem cell in humanized mouse bone marrow niche
| Project/Area Number |
21791008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Keio University |
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Principal Investigator |
SHIMA Haruko Keio University, 医学部, 助教 (80424167)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 造血幹細胞 / ニッチ / 白血病 / 急性骨髄性白血病 / 白血病幹細胞 / M-CSFR / NOGマウス / 細胞周期 / 低酸素 |
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| Research Abstract |
Using humanized mouse model, we showed that human hematopoietic stem cells acquired hypoxic state between 4 and 8 weeks after transplantation, followed by acquisition of quiescent state between 8 and 12 weeks after transplantation, and localized in endosteal lesion of engrafted bone marrow. We also developed MOZ-TIF2 induced AML mouse model and demonstrated that AML stem cells expressed high levels of M-CSFR. Further study is expected to analyze AML stem cells using humanized mouse model.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.2010
Author(s)
Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I.
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Journal Title
Nature Medicine. Vol.16、No.5
Pages: 580-585
Related Report
Peer Reviewed
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