| Project/Area Number |
21791011
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Teikyo University |
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Principal Investigator |
FUJISAWA Chie Teikyo University, 医学部, リサーチフェロー (10393000)
|
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| Co-Investigator(Renkei-kenkyūsha) |
WATTANAPPORN Bhadhaprasit 帝京大学, 医学部, リサーチフェロー (90583253)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Menkes病 / disulfiram / 銅代謝 / macularマウス / 治療 / 銅酵素活性 |
|---|
| Research Abstract |
Menkes disease (MD) is an X-linked recessive copper deficiency disorder with progressive neurological degeneration of copper metabolism caused by mutations in the ATP7A gene. It is not useful treatment for connective tissue and neurological degeneration. In this study, examined the effect of administration of combination with disulfiram and copper for macular mouse is a model for Menkes disease. It is suggested that combination with copper and disulfiram was useful methods for Menkes disease.
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