A pilot study aimed at clinical application of anti-tumor effects of eosinophils

• Project/Area Number: 21791017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Gunma Institute of Public Health and Environmental Sciences
• Principal Investigator: YAMADA Yoshiyuki Gunma Institute of Public Health and Environmental Sciences, 研究員 (80309252)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 小児腫瘍学 / 好酸球

Research Abstract

Eosinophils are white blood cells that can attack against tumor cells, which is called "anti-tumor effects of eosinophils". This study was aimed to determine the tumor cells that are easily weakened by eosinophils. In addition, the experiments to establish useful mouse models to check anti-tumor effects of eosinophils have done. This study may give useful information for clinical application of anti-tumor effects of eosinophils.

Research Products

• [Journal Article] Eosinophilic gastrointestinal disorders in infants : a Japanese case series. (2011)
  • Author(s): Yamada Y, Nishi A, Ebara Y, Kato M, Yamamoto H, Morita H, Nomura I, Matsumoto K, Hirato J, Hatakeyama SI, et al
  • Journal Title: Int Arch Allergy Immunol 155 Suppl 1 Pages: 40-45
  • Peer Reviewed
• [Journal Article] Differential effects of corticosteroids on serum eosinophil cationic protein and cytokine production in rhinovirus-and respiratory syncytial virus-induced acute exacerbation of childhood asthma. (2011)
  • Author(s): Kato M, Yamada Y, Maruyama K, Hayashi Y
  • Journal Title: Int Arch Allergy Immunol 155 Suppl 1 Pages: 77-84
  • Peer Reviewed
• [Journal Article] An 8-year-old boy with hypereosinophilic syndrome. (2011)
  • Author(s): Hosoki K, Nagao M, Iguchi K, Ihara T, Yamada Y, Higashigawa M, Kephart GM, Kita H, Fujisawa T
  • Journal Title: Int Arch Allergy Immunol 155 Suppl 1 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Different cytokine profile and eosinophil activation are involved in rhinovirus-and RS virus-induced acute exacerbation of childhood wheezing. (2011)
  • Author(s): Kato M, Tsukagoshi H, Yoshizumi M, Saitoh M, Kozawa K, Yamada Y, Maruyama K, Hayashi Y, Kimura H
  • Journal Title: Pediatr Allergy Immunol 22(1 Pt 2)
  • Peer Reviewed
• [Journal Article] 専門医のためのアレルギー学講座 好酸球増多を主徴とする疾患 好酸球増多症候群に見られる遺伝子異常と分子標的治療薬 (2011)
  • Author(s): 山田佳之
  • Journal Title: アレルギー 60(2) Pages: 167-177
• [Journal Article] Eosinophilic gastrointestinal disorders (EGIDs) in infants-A Japanese case series. (2011)
  • Author(s): Yamada Y, Nishi A, Ebara Y, Kato M, Yamamoto H, Morita H, et al.
  • Journal Title: Int Arch Allergy Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] An 8-year-old boy with hypereosinophilic syndrome. (2011)
  • Author(s): Hosoki K, Nagao M, Iguchi K, Ihara T, Yamada Y, Higashigawa M, et al.
  • Journal Title: Int Arch Allergy Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Differential Effects of Corticosteroids on Serum Eosinophil Cationic Protein and Cytokine Production in Rhinovirus- and RS virus-induced Acute Exacerbation of Childhood Asthma. (2011)
  • Author(s): Kato M, Yamada Y, Maruyama K, Hayashi Y.
  • Journal Title: Int Arch Allergy Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome. (2010)
  • Author(s): Seki M, Kimura H, Mori A, Shimada A, Yamada Y, Maruyama K, Hayashi Y, Agematsu K, Morio T, Yachie A, et al
  • Journal Title: Pediatr Int 52(4)
  • Peer Reviewed
• [Journal Article] FIP1L1/PDGFR alpha-associated systemic mastocytosis. (2010)
  • Author(s): Yamada Y, Cancelas JA
  • Journal Title: Int Arch Allergy Immunol 152 Suppl 1 Pages: 101-105
  • Peer Reviewed
• [Journal Article] Serum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthma. (2010)
  • Author(s): Kato M, Yamada Y, Maruyama K, Hayashi Y
  • Journal Title: Int Arch Allergy Immunol 152 Suppl 1 Pages: 62-66
  • Peer Reviewed
• [Journal Article] 【注目される好酸球関連疾患】 好酸球性胃腸炎 好酸球性消化管疾患(eosinophilic gastrointestinal disorders ; EGID)について (2010)
  • Author(s): 山田佳之
  • Journal Title: 臨床免疫・アレルギー科 54(4) Pages: 459-464
• [Journal Article] 好酸球増多症 好酸球増多症候群での最近の知見 (2010)
  • Author(s): 山田佳之
  • Journal Title: 日本小児血液学会雑誌 24(2) Pages: 77-84
  • NAID: 10026419288
• [Journal Article] Peripheral lymphocyte subset and serum cytokine profiles of patients with West syndrome. (2010)
  • Author(s): Shiihara T, Miyashita M, Yoshizumi M, Watanabe M, Yamada Y, Kato M
  • Journal Title: Brain Dev 32(9) Pages: 695-702
  • NAID: 10027492486
  • Peer Reviewed
• [Journal Article] A case of Baraitser-Winter syndrome with unusual brain MRI findings : pachygyria, subcortical-band heterotopia, and periventricular heterotopia. (2010)
  • Author(s): Shiihara T, Maruyama K, Yamada Y, Nishimura A, Matsumoto N, Kato M, Sakazume S
  • Journal Title: Brain Dev 32(6) Pages: 502-505
  • NAID: 10027491832
  • Peer Reviewed
• [Journal Article] Different cytokine profile and eosinophil activation are involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing. (2010)
  • Author(s): Kato M, Tsukagoshi H, Yoshizumi M, Saitoh M, Kozawa K, Yamada Y, et al.
  • Journal Title: Pediatr Allergy Immunol. Volume: Feb;22(1Pt 2)
  • Peer Reviewed
• [Journal Article] FIP1L1/PDGFR alpha-associated systemic mastocytosis. (2010)
  • Author(s): Yamada Y, Cancelas JA.
  • Journal Title: Int Arch Allergy Immunol. Volume: 152 Suppl1 Pages: 101-105
  • Peer Reviewed
• [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome. (2010)
  • Author(s): Seki M, Kimura H, Mori A, Shimada A, Yamada Y, Maruyama K, et al.
  • Journal Title: Pediatr Int. Volume: Aug;52(4)
  • Peer Reviewed
• [Journal Article] Serum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthma. (2010)
  • Author(s): Kato M, Yamada Y, Maruyama K, Hayashi Y.
  • Journal Title: Int Arch Allergy Immunol. Volume: 152 Suppl1 Pages: 62-66
  • Peer Reviewed
• [Journal Article] 好酸球性胃腸炎-好酸球性消化管疾患について- (2010)
  • Author(s): 山田佳之
  • Journal Title: 臨床免疫・アレルギー科 Volume: 54 Pages: 459-464
• [Journal Article] 好酸球増多症-好酸球増多症候群での最近の知見 (2010)
  • Author(s): 山田佳之
  • Journal Title: 日本小児血液学会誌 Volume: 24 Pages: 77-84
  • NAID: 10026419288
• [Journal Article] 好酸球増多症候群に見られる遺伝子異常と分子標的治療薬 (2010)
  • Author(s): 山田佳之
  • Journal Title: アレルギー Volume: 60(2) Pages: 167-177
• [Journal Article] Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia. (2009)
  • Author(s): Yamada Y, Cancelas JA, Rothenberg ME
  • Journal Title: Int Arch Allergy Immunol 149 Suppl 1 Pages: 102-107
  • Peer Reviewed
• [Journal Article] Thioredoxin reduces C-C chemokine-induced chemotaxis of human eosinophils. (2009)
  • Author(s): Kobayashi N, Yamada Y, Ito W, Ueki S, Kayaba H, Nakamura H, Yodoi J, Chihara J
  • Journal Title: Allergy 64(8) Pages: 1130-1135
  • Peer Reviewed
• [Journal Article] Peripheral lymphocyte subset and serum cytokine profiles of patients with West syndrome (2009)
  • Author(s): Shiihara T, Miyashita M, Yoshizumi M, Watanabe M, Yamada Y, Kato M.
  • Journal Title: Brain Dev. Nov 30(Epub)(Epub ahead of print)
  • NAID: 10027492486
  • Peer Reviewed
• [Journal Article] Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia (2009)
  • Author(s): Yamada Y, Cancelas JA, Rothenberg ME.
  • Journal Title: Int Arch Allergy Immunol. 149 Pages: 102-107
  • Peer Reviewed
• [Journal Article] A case of Baraitser-Winter syndrome with unusual brain MRI findings : pachygyria, subcortical-band heterotopia, and periventricular heterotopia (2009)
  • Author(s): Shiihara T, Maruyama K, Yamada Y, Nishimura A, Matsumoto N, Kato M, Sakazume S.
  • Journal Title: Brain Dev. May 23(Epub)(Epub ahead of print)
  • NAID: 10027491832
  • Peer Reviewed
• [Journal Article] Thioredoxin reduces C-C chemokine-induced chemotaxis of human eosinophils. (2009)
  • Author(s): Kobayashi N, Yamada Y, Ito W, Ueki S, Kayaba H, Nakamura H, Yodoi J, Chihara J.
  • Journal Title: Allergy. 64(8) Pages: 1130-5
  • Peer Reviewed
• [Presentation] 高好酸球血症のメカニズム、鑑別診断と好酸球性食道炎の最新知見 (2011)
  • Author(s): 山田佳之
  • Organizer: 平成22年度第2回新生児-乳児アレルギー疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-06
• [Presentation] 後方視的検討で発見された小児好酸球性食道炎 (2010)
  • Author(s): 山田佳之, 加藤政彦
  • Organizer: 第47回日本小児アレルギー学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-12-05
• [Presentation] 後方視的検討で発見された小児好酸球性食道炎 (2010)
  • Author(s): 山田佳之, 加藤政彦
  • Organizer: 第47回日本小児アレルギー学会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-12-05
• [Presentation] ライノウイルスおよびRSウイルスによる小児気管支喘息発作時の血清中サイトカイン/ケモカイン産生と好酸球活性化の相違 (2010)
  • Author(s): 加藤政彦, 山田佳之
  • Organizer: 第47回日本小児アレルギー学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-12-04
• [Presentation] ライノウイルスおよびRSウイルスによる小児気管支喘息発作時の血清中サイトカイン/ケモカイン産生と好酸球活性化の相違 (2010)
  • Author(s): 加藤政彦, 山田佳之
  • Organizer: 第47回日本小児アレルギー学会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-12-04
• [Presentation] 小児喘息と気道感染ライノおよびRSウイルスによる小児気管支喘息発作時の血清中サイトカイン産生と好酸球活性化の相違について (2010)
  • Author(s): 加藤政彦, 山田佳之
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] 小児消化管アレルギー小児での食道好酸球浸潤に関する後方視的検討 小児好酸球性食道炎患者は存在したか (2010)
  • Author(s): 山田佳之, 加藤政彦
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] 小児好酸球増多患者における末梢血CRTH2陽性Natural killer T細胞発現の検討 (2010)
  • Author(s): 山田佳之
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-11
• [Presentation] 好酸球性食道炎、好酸球性胃腸炎症候群について (2010)
  • Author(s): 山田佳之
  • Organizer: 第8回(平成22年度第1回)新生児-乳児アレルギー疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-06
• [Presentation] 好酸球性胃腸疾患の4例 (2010)
  • Author(s): 山田佳之, 西明, 江原佳史, 加藤政彦, 林泰秀
  • Organizer: アレルギー好酸球研究会2010
  • Place of Presentation: 東京
  • Year and Date: 2010-06-19
• [Presentation] 好酸球性胃腸疾患の4例 (2010)
  • Author(s): 山田佳之、西明、江原佳史、加藤政彦、林泰秀
  • Organizer: アレルギー・好酸球研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-19
• [Presentation] アスピリン喘息 疾患の紹介 好酸球性胃腸炎(ミニシンポジウム) (2010)
  • Author(s): 山田佳之
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-08
• [Presentation] アスピリン喘息疾患の紹介好酸球性胃腸炎 (2010)
  • Author(s): 山田佳之
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-08
• [Presentation] 気管支喘息発作時の原因ウイルスの同定とサイトカイン産生、好酸球活性化の検討(続報) (2010)
  • Author(s): 加藤政彦, 山田佳之, 丸山健一, 林泰秀
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-23
• [Presentation] 新生児・乳児消化管アレルギーの3例 (2010)
  • Author(s): 山田佳之, 江原佳史, 加藤政彦, 林泰秀
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-23
• [Presentation] Higher Frequency of Circulating CRTH2+ Natural Killer T Cells in Pediatric Patients with Eosinophilia. (2010)
  • Author(s): Yamada Y, Kourakata K, Kato M, Hayashi Y
  • Organizer: American Academy of Allergy, Asthma and Immunology 2010 Annual Meeting.
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2010-02-27
• [Presentation] Higher Frequency of Circulating CRTH2+ Natural Killer T Cells in Pediatric Patients with Eosinophilia (2010)
  • Author(s): Yamada Y, Kourakata K, Kato M, Hayashi Y.
  • Organizer: American Academy of Allergy, Asthma and Immunology 2010 Annual Meeting
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2010-02-27
• [Presentation] 結腸狭窄を認めた新生児・乳児消化管アレルギーの一例 (2009)
  • Author(s): 江原佳史, 山田佳之, 中嶋直樹, 西明, 畠山信逸, 丸山健一, 林泰秀
  • Organizer: 第46回日本小児アレルギー学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-06
• [Presentation] 注目される好酸球関連疾患 好酸球性胃腸炎(ワークショップ) (2009)
  • Author(s): 山田佳之
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-30
• [Presentation] 注目される好酸球関連疾患「好酸球性胃腸炎」 (2009)
  • Author(s): 山田佳之
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-30
• [Presentation] 好酸球と臨床・アレルギー病態 好酸球炎症と好酸球増多 好酸球増多をともなったBaraitser-Winter症候群の一例 (2009)
  • Author(s): 山田佳之, 加藤政彦
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-29
• [Presentation] 好酸球増多をともなった Baraitser-Winter 症候群の一例 (2009)
  • Author(s): 山田佳之、加藤政彦
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-29
• [Presentation] 好酸球と炎症性疾患 (2009)
  • Author(s): 山田佳之
  • Organizer: 第29回小児臨床検査研究会
  • Place of Presentation: 渋川(群馬)(教育講演)
  • Year and Date: 2009-10-17
• [Presentation] 好酸球性炎症とその評価 (2009)
  • Author(s): 山田佳之
  • Organizer: 第29回小児臨床検査研究会
  • Place of Presentation: 渋川市(群馬)
  • Year and Date: 2009-10-17
• [Presentation] 好酸球と炎症性疾患 (2009)
  • Author(s): 山田佳之
  • Organizer: 第10回 文翔館呼吸器研究会
  • Place of Presentation: 山形
  • Year and Date: 2009-09-18
• [Presentation] 好酸球と炎症性疾患 (2009)
  • Author(s): 山田佳之
  • Organizer: 第10回文翔館呼吸器研究会
  • Place of Presentation: 山形(特別講演)
  • Year and Date: 2009-09-08
• [Presentation] 小児好酸球増多患者におけるFIP1L1/PDGFRA融合遺伝子発現の検討 (2009)
  • Author(s): 山田佳之
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-27
• [Presentation] 小児好酸球増多患者におけるFIP1L1/PDGFRA融合遺伝子発現 (2009)
  • Author(s): 山田佳之
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2009-08-27
• [Presentation] FIP1L1/PDGFRA陽性好酸球増多症候群/好酸球性白血病(HES/CEL)マウスモデルにおける肥満細胞症 (2009)
  • Author(s): 山田佳之, Cancelas JA, Rothenberg ME
  • Organizer: アレルギー好酸球研究2009
  • Place of Presentation: 東京
  • Year and Date: 2009-06-20
• [Presentation] FIP1L1/PDGFRA陽性好酸球増多症候群/好酸球性白血病(HES/CEL)マウスモデルにおける肥満細胞症 (2009)
  • Author(s): 山田佳之、Cancelas JA, Rothenberg ME.
  • Organizer: アレルギー好酸球研究会2009
  • Place of Presentation: 東京
  • Year and Date: 2009-06-20