The role of Olig genes in mental retardation of Down syndrome

• Project/Area Number: 21791019
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TAKAKI Eiichi The Institute of Physical and Chemical Research, 神経遺伝研究チーム, 研究員 (50525590)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: ダウン症候群 / 精神発達遅滞 / オリゴデンドロサイト

Research Abstract

Down's syndrome (DS), which is characterized by mental retardation and typical facies, is caused by whole or partial trisomy of HSA21. However, the pathological mechanism of DS is unclear. We focused Olig genes as candidates of the causal genes of DS. Our observation suggests that Olig genes are one of the causal genes of multiple phenotypes in DS, such as mental retardation and abnormal oligodendrogenesis.

Research Products

• [Journal Article] Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. (2010)
  • Author(s): Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C.J., Yamakawa, K.
  • Journal Title: Cereb. Cortex. 20 Pages: 1131-1143
  • Peer Reviewed
• [Journal Article] Increased lipid peroxidation in Down's syndrome mouse models. (2009)
  • Author(s): Ishihara, K., Amano, K., Takaki, E., Ebrahim, A.S., Shimohata, A., Shibazaki, N., Inoue, I., Takaki, M., Ueda, Y., Sago, H., Epstein, C.J., Yamakawa, K.
  • Journal Title: J.Neurochem. 110 Pages: 1965-1976
  • Peer Reviewed