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The role of Olig genes in mental retardation of Down syndrome

Research Project

Project/Area Number 21791019
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

TAKAKI Eiichi  The Institute of Physical and Chemical Research, 神経遺伝研究チーム, 研究員 (50525590)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsダウン症候群 / 精神発達遅滞 / オリゴデンドロサイト
Research Abstract

Down's syndrome (DS), which is characterized by mental retardation and typical facies, is caused by whole or partial trisomy of HSA21. However, the pathological mechanism of DS is unclear. We focused Olig genes as candidates of the causal genes of DS. Our observation suggests that Olig genes are one of the causal genes of multiple phenotypes in DS, such as mental retardation and abnormal oligodendrogenesis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome.2010

    • Author(s)
      Ishihara, K., Amano, K., Takaki, E., Shimohata, A., Sago, H., Epstein, C.J., Yamakawa, K.
    • Journal Title

      Cereb. Cortex. 20

      Pages: 1131-1143

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased lipid peroxidation in Down's syndrome mouse models.2009

    • Author(s)
      Ishihara, K., Amano, K., Takaki, E., Ebrahim, A.S., Shimohata, A., Shibazaki, N., Inoue, I., Takaki, M., Ueda, Y., Sago, H., Epstein, C.J., Yamakawa, K.
    • Journal Title

      J.Neurochem. 110

      Pages: 1965-1976

    • Related Report
      2010 Final Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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