| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Research Abstract |
More than half of nephroblastoma didn't show abnormalities in responsible genes for tumorigenesis in fetal kidney. Therefore, there may be mutations in other tumor suppressor genes. Abnormalities of WTX and CTNNB known as tumor suppressor genes involved in WNT signaling pathway were detected in 22.8% and 26.3% of the 114 nephroblastomas. SNP array analysis clarified chromosomal abnormalities of APC(5q21-22), AXIN1(16p13) or AXIN2(17q23-24) coding regions in a little bit of cases. By direct sequencing analysis, a mutation of APC gene was indentified in one of 59 tumors which didn't have any abnormalities in known responsible genes. Patients with an abnormality in WTX gene were poor outcome than those without(p=0.0402).
|
