| Project/Area Number |
21791030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KITANISHI Ryuta Tohoku University, 大学院・医学系研究科, 非常勤講師 (20436116)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 人工胎盤 / 人工羊水 / 人工子宮 / 胎児循環 / 膜型人工肺 / 動脈管 / マイクロスフェア法 |
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| Research Abstract |
The purpose of this study was to develop an artificial placenta in the form of a pumplessarteriovenous extracorporeal life support circuit that could maintain fetal circulation.Sheep fetuses survived for more than 15 hours with the artificial placenta while maintaining fetal circulation. Dopamine could increase the mean arterial pressure transiently. However, blood lactatewas increased and the cardiac performance was gradually deteriorated over time even while the gas exchange ofthe artificial placenta was maintained. Elevated mean arterial pressurein our experiment might be achieved by systemic vasoconstriction, which led to decreased systemic organ flowdue to increased artificial placental flow, resulted in systemic circulatory failure. It may be important to retain both systemic and circuit circulation by controlling each resistance.
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