Determination of the cause of Long QT Syndrome in children

Research Project

Project/Area Number	21791031
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Embryonic/Neonatal medicine
Research Institution	Yamagata University
Principal Investigator	OTAGIRI Tesshu Yamagata University, 医学部, 助教 (30400550)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	QT延長症候群 / 遺伝性不整脈 / イオンチャネル / ブルガダ症候群 / ブルガダ症 / イオンチャネ / イオンチャンネル
Research Abstract	We carried out genetic analysis of Long-QT Syndrome(LQT), an inherited cardiac arrhythmia, in five unrelated LQT families. DNA sequence analyses revealed KCNQ1 mutations(LQT1) in three families and KCNH2 mutations(LQT2) in two families. Genetic analysis may provide a useful tool for diagnosis and management of LQT.