Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

• Project/Area Number: 21791032
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: University of Tsukuba
• Principal Investigator: SAITO Makoto 筑波大学, 医学医療系, 講師 (80535021)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 新生児医学 / Adiponectin / 早産児 / メタボリックシンドローム / small-for-gestational age / 遺伝子多型 / 成人病胎児発症仮説

Research Abstract

We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight SD score than those homozygous for the C allele. However, this difference wasn't significant after adjustment for cord blood adiponectin. The rs266729 SNP was strongly associated with cord blood adiponectin. This association remained after adjustment for birth weight SD score. Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin.

Research Products

• [Journal Article] Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth (2012)
  • Author(s): Saito M, Kamoda T, Nishimura K, Miyazono Y, Kanai Y, Kato Y, Iwabuchi A, Fukushima H, Hamada H, Arinami T, Sumazaki R, Noguchi E
  • Journal Title: J Hum Genet Volume: 57(2) Issue: 2 Pages: 109-14
  • DOI: 10.1038/jhg.2011.134
  • NAID: 10030711598
  • Peer Reviewed
• [Journal Article] Changes in serum adiponectin levels from birth to term-equivalent age are associated with postnatal weight gain in preterm infants (2011)
  • Author(s): Saito M, Nishimura K, Nozue H, Miyazono Y, Kamoda T
  • Journal Title: Neonatology Volume: 100(1) Pages: 93-8
• [Journal Article] Changes in Serum Adiponectin Levels from Birth to Term-Equivalent Age Are Associated with Postnatal Weight Gain in Preterm Infants. (2011)
  • Author(s): Saito M, et al.
  • Journal Title: Neonatology. Volume: 100 Pages: 93-98
  • Peer Reviewed
• [Presentation] アディポネクチン遺伝子多型が胎児発育に及ぼす影響 (2011)
  • Author(s): 齋藤誠ら
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール
  • Year and Date: 2011-08-13
• [Presentation] 早産児における生後早期の体重増加と血清Adiponectin値についての検討 (2010)
  • Author(s): 齋藤誠ら
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: いわて県民情報交流センター(アイーナ)
  • Year and Date: 2010-04-25
• [Presentation] 早産児における生後早期の体重増加と血清Adiponectin値についての検討 (2010)
  • Author(s): 齋藤誠, ら
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: いわて県民情報交流センター(岩手県)
  • Year and Date: 2010-04-25
• [Presentation] 早産児における血清アディポネクチンの出生後の推移 (2009)
  • Author(s): 齋藤誠
  • Organizer: 第54回未熟児新生児学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2009-12-01