Elucidated of environmental and genetic effects on the neural network disorders.
| Project/Area Number |
21791036
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
MATSUMOTO Yoshiki Kagawa University, 農学部, 助教 (90335844)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | ニューラルネットワーク / アルコール曝露動物 / 幹細胞性の保持 / 神経変性疾患 / 環境要因 / 迷走神経 / ニューラルネットワーク形成障害 / 環境因子 / 細胞膜表面 / シナプス膜 / アルコール曝露 / 神経細胞 / グリア細胞 / 細胞の脆弱性 |
|---|
| Research Abstract |
In this study, we elucidated the effects of environmental and genetic cues for the neural network formations. First, to clarify the response of environmental stress were analyzed using neuronal progenitor cells. Those effects and related signal transcription on neuro-progenitor cells were clearly promoted rescue on cell cycle and neuronal stretched shapes. It may have been involving survival response in neuro progenitor cell that was expressing the receptor of neuronal growth factors and that shown responsible for several environment cues. Interestingly, neuronal injured adult rat brain indicated similar morphological alteration that has promoted the autocrine-like and diacrine-like formation at pre- and post- synaptic membrane during a non-excitable condition.
|
Report
(3 results)
Research Products
(38 results)
-
-
-
-
-
-
[Journal Article] Sharing first authorship.TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors.2010
Author(s)
Elmi M, Matsumoto Y, Zeng ZJ, Chavali PL, Yang W, Uemura A, Nishikawa S, Moshiri A, Tajima N, Agren H, Funa K.
-
Journal Title
Molecular and Cellular Neuroscience 45
Pages: 121-131
Related Report
Peer Reviewed
-
[Journal Article] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum.2010
Author(s)
Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y.
-
Journal Title
Neuroscience 165
Pages: 485-491
Related Report
Peer Reviewed
-
[Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus.2010
Author(s)
Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y.
-
Journal Title
Acta Neurobiol Exp(Wars) 68
Pages: 49-484
Related Report
Peer Reviewed
-
[Journal Article] Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus.2010
Author(s)
UenoT, Miki T, Wang ZY, Yokoyama T, Lee KY, Kusaka T, Warita K, Sumitani K, Matsumoto Y, Yakura T, Liu JQ, Bedi KS, Takeuchi Y.
-
Journal Title
Current Neurobiology 1
Pages: 40-45
Related Report
Peer Reviewed
-
-
[Journal Article] Nerve growth factor and receptors are significantly affected by histamine stimulus through H1 receptor in pancreatic carcinoma cells.2010
Author(s)
Wang ZY, Ding Y, Miki T, Warita K, Matsumoto Y, Takeuchi Y, Wang SJ, Feng JG, Liu W, Wang YD, Wang XL, Wang YH, Liu Y, Shan BE.
-
Journal Title
Molecular Medicine Reports 3
Pages: 103-109
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
