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The efrect of environmental contaminants on placental nutrient transport

Research Project

Project/Area Number 21791049
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SHIBATA Eiji  産業医科大学, 医学部, 准教授 (90419838)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords環境科学物質 / 胎盤 / 栄養素輸送 / 子宮内胎児発育不全 / アミノ酸輸送 / 環境化学物質 / 胎盤機能 / 栄養素輸送機能 / 子宮内胎児発育遅延 / 胎盤栄養素輸送 / 環境汚染 / 小児発達障害
Research Abstract

Polychlorinated Biphenyls(PCBs)exposure decreases the infant birth weight in the previous report, but the underline echanism isno known. we report that PCBs decrease the Placental syncytiotrophoblast Volume and increase Placental Growth Factor (PlGF) in the placenta of normal pregnancy. The increase of PlGF may be an adaptive response to maintain the placental nutrient transport function. Like a tobacco smoking, PCBs exposure has a unique profile of PIGF and in pregnant women. Even if the PCBs exposure is very low level, placental nutrient function may be changed. In vitro experiments, aldehyde analogue including glutaraldehyde, formaldehyde decreased system Aamino acid transport activity but acetaldehyde didnot in the placental villous fragment. Glutaraldehyde had the strongest effect on it. Heavy nletals including arsenic, cadnlium decreased system A amino acid transport activity but methylmercury did not in the placental villous fragment. Arsenic had the strongest effect on it. Plastic legins including toluene diisocyanate, phthalic anhydride, and methyl acrylate decreased system Aamino acid transport activity but acrylamide did not in the placental villous fragment. Toluene diisocyanate had the strongest effect on it. Allof the chemicals and heavy metals did not increase lactase dehydrogenase concentration in the culture media.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (19 results)

  • [Journal Article] Polychlorinated Biphenyls (PCBs) decrease the Placental Syncytiotrophoblast Volume and increase Placental Growth Factor (PIGF) in the placenta of normal pregnancy2013

    • Author(s)
      Mayumi Tsuji; Yukiyo Aiko; David J Askew; Toshiro Kawamoto; Tohru Hachisuka;Chihaya Kooriyama;Mai Myoga; Chiharu Tomonaga; Fumio Matsumura; Ayumi Anan; Masayuki Tanaka; Hsu-Sheng Yu; Yasuko Fujisawa; Reiko Suga; Eiji Shibata
    • Journal Title

      PLACENTA

      Volume: (In press) Issue: 7 Pages: 1-5

    • DOI

      10.1016/j.placenta.2013.03.007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠糖尿病/糖尿病合併妊娠の胎盤におけるアミノ酸輸送機能の検討2013

    • Author(s)
      茗荷舞、愛甲悠希代、蜂須賀 徹、柴田 英治
    • Journal Title

      日本周産期新生児学会雑誌

      Volume: 49(1) Pages: 261-266

    • Related Report
      2012 Final Research Report
  • [Journal Article] 妊娠糖尿病/糖尿病合併妊娠の胎盤におけるアミノ酸輸送機能の検討2013

    • Author(s)
      茗荷舞、愛甲悠希代、蜂須賀 徹、柴田 英治
    • Journal Title

      日本周産期新生児学会雑誌

      Volume: 49 (1) Pages: 261-266

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation for the Effect of the Environmental Contaminants Exposure on the Placental Amino Acid Transport Activity2012

    • Author(s)
      Eiji Shibata, Toshihiro Kawamoto, Yukiyo Aiko, David J Askew, Reiko Suga, Mai Myoga, Toru Hachisuga
    • Journal Title

      The official Journal of the Society for Gynecologic Investigation

      Volume: 19

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Restricted Nutrient Supply from Mother to Fetus Is Associated with Up-regulated Placental Amino Acid Transporter and mTOR Protein Expression2012

    • Author(s)
      Yukiyo Aiko, Eiji Shibata, David J Askew, Toru Hachisuga
    • Journal Title

      The official Journal of the Society for Gynecologic Investigation

      Volume: 19

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 妊娠中の体重変化が胎盤アミノ酸輸送機能に与える影響2011

    • Author(s)
      菅 礼子、愛甲悠希代、David J Askew、 川本俊弘、蜂須賀徹、田中政幸、辻 真弓、 阿南あゆみ、柴田英治
    • Journal Title

      産婦人科治療

      Volume: vol.103 no.5 Pages: 550-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠中の体重変化が胎盤アミノ酸輸送機能に与える影響2011

    • Author(s)
      菅礼子、愛甲悠希代、David J Askew、川本俊弘、蜂須賀徹、田中政幸、辻真弓、阿南あゆみ、柴田英治
    • Journal Title

      産婦人科治療

      Volume: 103 Pages: 550-51

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 正常胎盤におけるmammalian target of rapamycin(mTOR)シグナル活性とアミノ酸輸送蛋白の発現の検討2011

    • Author(s)
      柴田英治、愛甲悠希代、David J Askew、菅礼子、川本俊弘、蜂須賀徹
    • Journal Title

      日本妊娠高血圧学会雑誌

      Volume: 19 Pages: 137-137

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 母体栄養状態と妊娠高血圧症候群、胎児発育不全の胎盤におけるアミノ酸輸送蛋白の検討2011

    • Author(s)
      愛甲悠希代、柴田英治、David J Askew、菅礼子、川本俊弘、蜂須賀徹
    • Journal Title

      日本妊娠高血圧学会雑誌

      Volume: 19 Pages: 89-89

    • Related Report
      2011 Annual Research Report
  • [Presentation] Investigation for the Effect of the Environmental Contaminants Exposure on the Placental Amino Acid Transport Activity2012

    • Author(s)
      Eiji Shibata, Toshihiro Kawamoto, Yukiyo Aiko, David J Askew, Reiko Suga, Mai Myoga, Toru Hachisuga
    • Organizer
      59^<th> Annual Meeting Society for Gynecologic Investigation
    • Place of Presentation
      Manchester Grand Hyatt (San Diego, CA, USA)
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Restricted Nutrient Supply from Mother to Fetus Is Associated with Up-regulated Placental Amino Acid Transporter and mTOR Protein Expression2012

    • Author(s)
      Yukiyo Aiko, Eiji Shibata, David J Askew, Toru Hachisuga
    • Organizer
      59^<th> Annual Meeting Society for Gynecologic Investigation
    • Place of Presentation
      Manchester Grand Hyatt (San Diego, CA, USA)
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] -Investigation for the Effect of the Environmental Contanlinants Exposure on the Placental Amino Acid Transport Activity-2012

    • Author(s)
      Eiji Shibata, Toshihiro Kawamoto, Yukiyo Aiko, David J Askew, Rei Suga, Mai Myoga, Toru Hachisuga
    • Organizer
      59th Annual Meeting Society for Gynecologic Investigation
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] -Restricted Nutrient Supply from Mother to Fetus IsAssociated with Up-regulated Placental Amino Acid Transporter and mTOR Protein Expression-2012

    • Author(s)
      Yukiyo Aiko, Eiji Shibata, David J Askew, Toru Hachisuga
    • Organizer
      59th Annual Meeting Society for Gynecologic Investigation
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Investigation of the Effect of Environmental Contaminants Exposure on the Placental Amino Acid Transport Activity2012

    • Author(s)
      Eiji Shibata, Yukiyo Aiko, David J Askew, Rei Suga, Mayumi Tsuji, Toru Hachisuga, Toshihiro Kawamoto
    • Organizer
      The 3^<rd> PPTOX conference
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] Investigation of the Effect of Environmental Contaminants Exposure on the Placental Amino Acid Transport Activity2012

    • Author(s)
      Shibata E
    • Organizer
      The 3rd PPTOX conference
    • Place of Presentation
      Espace Saint Martin, Paris, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] 妊娠中の母体の体重変化と胎盤栄養素輸送機能についての検討2011

    • Author(s)
      茗荷舞、愛甲悠希代、柴田英治、David J Askew、菅礼子、川本俊弘、吉村和晃、蜂須賀徹
    • Organizer
      第27回日本糖尿病・妊娠学会年次学術集会
    • Place of Presentation
      神戸商工会議所(神戸市)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 正常胎盤におけるmammalian target of rapamycin(mTOR)シグナル活性とアミノ酸輸送蛋白の発現の検討2011

    • Author(s)
      柴田英治、愛甲悠希代、David J Askew、菅礼子、川本俊弘、蜂須賀徹
    • Organizer
      第32回日本妊娠高血圧学会
    • Place of Presentation
      金沢歌劇座(金沢市)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 母体栄養状態と妊娠高血圧症候群、胎児発育不全の胎盤におけるアミノ酸輸送蛋白の検討2011

    • Author(s)
      愛甲悠希代、柴田英治、David J Askew、菅礼子、川本俊弘、蜂須賀徹
    • Organizer
      第32回日本妊娠高血圧学会
    • Place of Presentation
      金沢歌劇座(金沢市)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 妊娠中の労働が胎盤機能に与える影響の検討2011

    • Author(s)
      愛甲悠希代、柴田英治、David J Askew、蜂須賀徹、菅礼子、阿南あゆみ、田中政幸、辻真弓、川本俊弘
    • Organizer
      日本産業衛生学会九州地方会
    • Place of Presentation
      アバンセ(佐賀県立男女共同参画センター・佐賀県立生涯学習センター)(佐賀市)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 母体の体重変化が胎児・胎盤機能に与える影響2011

    • Author(s)
      菅礼子、愛甲悠希代、柴田英治、David J Askew、蜂須賀徹、阿南あゆみ、田中政幸、辻真弓、川本俊弘
    • Organizer
      日本産業衛生学会九州地方会
    • Place of Presentation
      アバンセ(佐賀県立男女共同参画センター・佐賀県立生涯学習センター)(佐賀市)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 妊娠中の労働が胎盤機能に与える影響の検討2011

    • Author(s)
      愛甲悠希代、柴田英治、David J. Askew、 蜂須賀徹、菅 礼子、阿南あゆみ、田中政幸、辻真弓、川本俊弘
    • Organizer
      日本産業衛生学会九州地方会
    • Place of Presentation
      佐賀
    • Year and Date
      2011-07-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 母体の体重変化が胎児・胎盤機能に与える影響2011

    • Author(s)
      菅 礼子、愛甲悠希代、柴田英治、Davidj. Askew、蜂須賀徹、阿南あゆみ、田中政幸、 辻真弓、川本俊弘
    • Organizer
      日本産業衛生学会九州地方会
    • Place of Presentation
      佐賀
    • Year and Date
      2011-07-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 正常胎盤におけるmammalian target of rapamycin(mTOR)シグナル活性とアミノ酸輸送蛋白の発現の検討2011

    • Author(s)
      柴田英治、愛甲悠希代、David j. Askew、菅 礼子、川本俊弘、蜂須賀徹:
    • Organizer
      第32回日本妊娠高血圧学会
    • Place of Presentation
      金沢
    • Related Report
      2012 Final Research Report
  • [Presentation] 母体栄養状態と妊娠高血圧症候群、胎児発育不全の胎盤におけるアミノ酸輸送蛋白の検討2011

    • Author(s)
      愛甲悠希代、柴田英治、David j. Askew、菅 礼子、川本俊弘、蜂須賀徹
    • Organizer
      第32回日本妊娠高血圧学会
    • Place of Presentation
      金沢
    • Related Report
      2012 Final Research Report
  • [Presentation] 妊娠中の母体の体重変化と胎盤栄養素輸送機能についての検討2011

    • Author(s)
      茗荷 舞、愛甲悠希代、柴田英治、David Askew、菅 礼子、川本俊弘、吉村和晃、蜂須賀徹
    • Organizer
      第27回日本糖尿病・妊娠学会年次学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム「子宮内胎児発育遅延の基礎と臨床」喫煙と胎児発育制限-胎盤アミノ酸輸送および妊娠高血圧症候群との関連について-2010

    • Author(s)
      柴田英治、愛甲悠希代、蜂須賀徹、川本俊弘、田中政幸、阿南あゆみ
    • Organizer
      第18回日本胎盤学会学術集会
    • Place of Presentation
      ホテル日航熊本(熊本市)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] The investigation for the relationship between environmental contaminants and placental nutrient transport insufficiency2010

    • Author(s)
      Shibata E
    • Organizer
      Research Conference in Magee Womens Research Institute, Univ.of Pittsburgh
    • Place of Presentation
      Magee Womens Research Institute, Univ.of Pittsburgh
    • Year and Date
      2010-03-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 「喫煙と胎児発育制限」-胎盤アミノ酸輸送および妊娠高血圧症候群との関連 について-」シンポジウム「子宮内胎児発育遅延の基礎と臨床」2010

    • Author(s)
      柴田英治、David A. Askew、愛甲悠希代、蜂須賀徹、川本俊弘、田中政幸、阿南あゆみ
    • Organizer
      第18回日本胎盤学会学術集会
    • Place of Presentation
      熊本
    • Related Report
      2012 Final Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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