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Development of therapeutic strategies for periventricular leukomalacia based on the activation of microglia and the inhibition of inflammatory mediatior.

Research Project

Project/Area Number 21791051
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center

Principal Investigator

TAKEI Shiro  Institute for Developmental Research, Aichi Human Service Center, 病理学部, リサーチレジデント (60398576)

Research Collaborator SHIMADA Atsuyoshi  愛知県心身障害者コロニー発達障害研究所, 病理学部, 室長 (50311444)
CHIBA Yoichi  愛知県心身障害者コロニー発達障害研究所, 病理学部, 主任研究員 (30372113)
SHIMIZU Takao  東京大学, 医学部, 教授 (80127092)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳室周囲白質軟化症 / プロスタグランジン / ミクログリア / 脂質メディエーター
Research Abstract

Although periventricular leukomalacia (PVL) is one of the most common brain injuries in premature infants, there has been no effective treatment. We investigated the mechanism of PVL in relationship to microglia. We found that hematopoietic prostaglandin D synthase and microsomal prostaglandin E synthase were upregulated in glial cytoplasms in white matter of infant brains during hypoxic/ischemic (H/I) insults following maternal infection. We suggest that these prostaglandins may elevated the risk of PVL via microglial activation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (21 results) Remarks (1 results)

  • [Journal Article] Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.2011

    • Author(s)
      Yoshikawa K**, Takei S**, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A(**同列筆頭著者)
    • Journal Title

      Brain Research 1367

      Pages: 22-32

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Defects in cytokine-mediated neuroprotective glial responses toexcitotoxic hippocampal injury in senescence-accelerated mouse.2011

    • Author(s)
      Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Shimada A
    • Journal Title

      Brain Behavior and Immunity 25

      Pages: 83-100

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice.2011

    • Author(s)
      Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M, Shimada A
    • Journal Title

      Neuropathology 31

      Pages: 20-28

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.2011

    • Author(s)
      Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
    • Journal Title

      Brain Research

      Volume: 1367 Pages: 22-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse.2011

    • Author(s)
      Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Shimada A
    • Journal Title

      Brain Behavior and Immunity

      Volume: 25 Pages: 83-100

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice.2011

    • Author(s)
      Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M, Shimada A
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 20-28

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eosin-shadow method : a selective enhancement of light-microscopic visualization of pancreatic zymogen granules on hematoxylin-eosin sections.2010

    • Author(s)
      Takei S, Tokuhira Y, Shimada A, Hosokawa M, Fukuoka S
    • Journal Title

      Anatomical Science International 85

      Pages: 245-250

    • NAID

      10031162229

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration.2010

    • Author(s)
      Furukawa A, Oikawa S, Hasegawa-Ishii S, Chiba Y, Kawamura N, Takei S, Yoshikawa K, Hosokawa M, Kawanishi S, Shimada A
    • Journal Title

      Mechanical Ageing and Develpoment 131

      Pages: 379-388

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of aging brain in SAMP10 mouse : a model of age-related cerebral degeneration.2010

    • Author(s)
      Furukawa A, Oikawa S, Hasegawa-Ishii S, Chiba Y, Kawamura N, Takei S, Yoshikawa K, Hosokawa M, Kawanishi S, Shimada A
    • Journal Title

      Mechanical Ageing and Develpoment

      Volume: 131 Pages: 379-388

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The eosin-shadow method : a selective enhancement of light-microscopic visualization of pancreatic zymogen granules on hematoxylin-eosin sections.

    • Author(s)
      Shiro Takei, et al.
    • Journal Title

      Anatomical Science International (印刷中)

    • NAID

      10031162229

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Immunohistochemical demonstration of enhanced prostaglandin F2alpha production following kainic acid-induced seizures in rat hippocampus.2011

    • Author(s)
      Takei S, Hasegawa-Ishii S, Furukawa A, Chiba Y, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
    • Organizer
      第116 回日本解剖学会総会・全国学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Immunohistochemical demonstration of enhanced prostaglandin F2alpha production following kainic acid induced seizures in rat hippocampus.2011

    • Author(s)
      Takei S, Hasegawa-Ishii S, Furukawa A, Chiba Y, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] The distribution of prostamide/prostaglandin F synthase in the developing and adult mouse central nervous system.2010

    • Author(s)
      Shimada A, Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Woodward DF, Watanabe K
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] The distribution of prostamide/prostaglandin F synthase in the developing and adult mouse central nervous system2010

    • Author(s)
      Shimada A, Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Woodward DF, Watanabe K
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prostamide/prostaglandin F synthaseのマウス中枢神経系および培養オリゴデンドロサイトにおける分布2010

    • Author(s)
      千葉陽一、島田厚良、吉川圭介、武井史郎、石井さなえ、古川絢子、河村則子、Woodward DF、渡部紀久子
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Microglia as a potential target for age-related neurodegeneration in SAMP10 mice.2010

    • Author(s)
      Ishii S, Inaba M, Takei S, Furukawa A, Chiba Y, Kawamura N, Hosokawa M, Ikehara S, Shimada A
    • Organizer
      第33回日本基礎老化学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Microglia as a potential target for age-related neurodegeneration in SAMP10 mice2010

    • Author(s)
      Ishii S, Inaba M, Takei S, Furukawa A, Chiba Y, Kawamura N, Hosokawa M, Ikehara S, Shimada A
    • Organizer
      第33回日本基礎老化学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] The distribution of prostamide/prostaglandin F synthase in the developing and adult mouse central nervous system.2010

    • Author(s)
      Shimada A, Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Woodward DF, Watanabe K
    • Organizer
      Keystone symposia
    • Place of Presentation
      京都
    • Year and Date
      2010-06-09
    • Related Report
      2010 Final Research Report
  • [Presentation] The distribution of prostamide/prostaglandin F synthase in the developing and adult mouse central nervous system2010

    • Author(s)
      Shimada A, Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Woodward DF, Watanabe K
    • Organizer
      Keystone symposia
    • Place of Presentation
      京都
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 興奮毒性による海馬損傷における酸化損傷タンパク質の生成2010

    • Author(s)
      古川絢子、島田厚良、河村則子、武井史郎、千葉陽一、石井さなえ、細川昌則
    • Organizer
      第51回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Glial cytoplamic inclusionsはaggresomeとしての性格を有する2009

    • Author(s)
      千葉陽一、島田厚良、武井史郎、河村則子、石井さなえ、古川絢子、佐々木健介、岩城徹、細川昌則
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 興奮毒性による海馬損傷における酸化損傷タンパク質の生成2009

    • Author(s)
      古川絢子、島田厚良、河村則子、武井史郎、千葉陽一、石井さなえ、細川昌則
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 老化促進モデルマウスにおけるミクログリアの異常と神経変性2009

    • Author(s)
      島田厚良、石井さなえ、武井史郎、河村則子、古川絢子、千葉陽一、細川昌則
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] The usefulness of oolong tea extract in an electron staining with platinum blue 6th2009

    • Author(s)
      Takei S, Shimada A, Hosokawa M, Inaga S
    • Organizer
      ISEM09
    • Place of Presentation
      神戸
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] The usefulness of oolong tea extract in an electron staining with platinum blue.2009

    • Author(s)
      Shiro Takei, et al.
    • Organizer
      医学生物学電子顕微鏡学会
    • Place of Presentation
      神戸大学百年記念館(兵庫)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] SAMP10にみられるミクログリアの形態異常と興奮毒性に対する応答異常2009

    • Author(s)
      石井さなえ、島田厚良、千葉陽一、古川絢子、河村則子、武井史郎、細川昌則
    • Organizer
      第24回老化促進モデルマウス(SAM)研究協議会
    • Place of Presentation
      松本
    • Year and Date
      2009-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] SAMP10への骨髄内骨髄移植によるミクログリア再生を介した神経変性の制御2009

    • Author(s)
      島田厚良、石井さなえ、稲葉宗夫、河村則子、武井史郎、古川絢子、千葉陽一、細川昌則、池原進
    • Organizer
      第24回老化促進モデルマウス(SAM)研究協議会
    • Place of Presentation
      松本
    • Year and Date
      2009-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 加齢性神経変性疾患における封入体形成へのaggresomeの関与2009

    • Author(s)
      千葉陽一、島田厚良、武井史郎、河村則子、石井さなえ、古川絢子、細川昌則
    • Organizer
      日本基礎老化学会第32回大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Glial cytoplamic inclusionsはaggresomeとしての側面を有する2009

    • Author(s)
      千葉陽一、島田厚良、武井史郎、河村則子、石井さなえ、古川絢子、佐々木健介、岩城徹、細川昌則
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 老化促進モデルマウスにみられるミクログリアの形態異常と興奮毒性に対する応答異常2009

    • Author(s)
      石井さなえ、島田厚良、千葉陽一、古川絢子、河村則子、武井史郎、細川昌則
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] SAMP10の加齢性神経変性に伴うタンパク質発現変化に関するプロテオミクス解析2009

    • Author(s)
      古川絢子、島田厚良、及川伸二、千葉陽一、石井さなえ、河村則子、武井史郎、細川昌則
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.inst-hsc.jp/d-pathology/index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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