Expression regulation of basement membrane proteins by transcription factor of epithelial to mesenchymal transition

• Project/Area Number: 21791055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: NAKAJIMA Koji Hirosaki University, 大学院・医学研究科, 助教 (70374832)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 遺伝子 / シグナル伝達 / 発現制御 / 転写因子

Research Abstract

Recent studies show that TGF-β is a key cytokine of EMT and zinc-finger transcription factor Snail also is a master transcription factor of EMT. Our group has been investigating on molecular mechanisms of expression regulation of basement membrane proteins and examining promoter analysis of BBAG1 and type VII collagen genes. The purpose of this study is to clarify how transcription factor Snail induced by TGF-β modulate expression of basement membrane proteins. The results showed that TGF-β induced expression of basement membrane proteins, resulting in suppression of EMT. Furthermore, transcription factor Snail played an important role in this phenomenon.

Research Products

• [Journal Article] Disseminated lupus vulgaris misdiagnosed as port-wine stain. (2010)
  • Author(s): Takeuchi S, Nakano H, Rokunohe D, Nishizawa A, Kenoko T, Aizu T, Nakajima K, Matsuzaki Y, Sawamura D.
  • Journal Title: J Dermatol 37 Pages: 916-918
  • Peer Reviewed
• [Journal Article] Proliferating trichilemmal tumor developing in nevus sebaceous. (2010)
  • Author(s): Takeda H, Ikenaga S, Kaneko T, Nakajima K, Harada K, Hanada K, Sawamura D.
  • Journal Title: Eur J Dermatol 20 Pages: 664-665
  • Peer Reviewed
• [Journal Article] Giant cutaneous granular cell tumour with papillomatous appearance. (2010)
  • Author(s): Rokunohe D, Nakano H, Oshima H, Nakajima K, Aizu T, Kaneko T, Sawamura D.
  • Journal Title: Clin Exp Dermatol 35
  • Peer Reviewed
• [Journal Article] Multiple eruptive dermatofibromas associated with Hashimoto's thyroiditis and myasthenia gravis. (2010)
  • Author(s): Kimura Y, Kaneko T, Akasaka E, Nakajima K, Aizu T, Nakano H, Sawamura D.
  • Journal Title: Eur J Dermatol 20 Pages: 538-539
  • Peer Reviewed
• [Journal Article] Leukemia cutis is an early sign of blast transformation that may mimica common skin disease : sycosis-like eruptions in chronic myelomonocytic leukemia. (2010)
  • Author(s): Takeuchi S
  • Journal Title: J Dermatol Volume: 37 Pages: 916-918
  • Peer Reviewed
• [Journal Article] Proliferating trichilemmal tumor developing in nevus sebaceous. (2010)
  • Author(s): Takeda H
  • Journal Title: Eur J Dermatol Volume: 20 Pages: 664-665
  • Peer Reviewed
• [Journal Article] Giant cutaneous granular cell tumour with papillomatous appearance. (2010)
  • Author(s): Rokunohe D
  • Journal Title: Clin Exp Dermatol Volume: 35
  • Peer Reviewed
• [Journal Article] Multiple eruptive dermatofibromas associated with Hashimoto's thyroiditis and myasthenia gravis. (2010)
  • Author(s): Kimura Y
  • Journal Title: Ear J Dermatol Volume: 20 Pages: 538-539
  • Peer Reviewed
• [Journal Article] A linear basal cell carcinoma undergoing spontaneous regression. (2009)
  • Author(s): Takiyoshi N, Nakano H, Kaneko T, Aizu T, Nakajima K, Akasaka E, Rokunohe D, Sawamura D.
  • Journal Title: Clin Exp Dermatol 34
  • Peer Reviewed
• [Journal Article] Multiple desmoplastic trichoepitheliomas with ossification and cholesterol deposition. (2009)
  • Author(s): Takiyoshi N, Nakano H, Kaneko T, Aizu T, Nakajima K, Akasaka E, Rokunohe D, Sawamura D.
  • Journal Title: Clin Exp Dermatol 34 Pages: 634-635
  • Peer Reviewed
• [Journal Article] Dermascopy of eccrine poroma with calcification. (2009)
  • Author(s): Nishikawa Y, Kaneko T, Kakiyoshi N, Aizu T, Nakajima K, Matsuzaki Y, Nakano H, Sawamura D.
  • Journal Title: J Dermatol Case Rep 3 Pages: 52-54
  • Peer Reviewed
• [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa. (2008)
  • Author(s): Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, Murai T, Tamai K, Sawamura D.
  • Journal Title: J Dermatol 35 Pages: 336-340
  • NAID: 10024297026
  • Peer Reviewed
• [Journal Article] Identification of Skn-1n, a splice variant that is induced by high calcium concentration and specifically expressed in normal human keratinocytes. (2008)
  • Author(s): Nakajima K, Tamai K, Yamazaki T, Toyomaki Y, Nakano H, Uitto J, Sawamura D.
  • Journal Title: J Invest Dermatol 128 Pages: 1336-1339
  • Peer Reviewed
• [Journal Article] Papillon-Lefevre syndrome and malignant melanoma : a high incidence of melanoma development in Japanese palmoplantar keratoderma patients. (2008)
  • Author(s): Nakajima K, Nakano H, Takiyoshi N, Rokunohe A, Ikenaga S, Aizu T, Kaneko T, Mitsuhashi Y, Sawamura D.
  • Journal Title: Dermatology 217 Pages: 58-62
  • Peer Reviewed
• [Journal Article] A case of zosteriform metastatic skin cancer. (2008)
  • Author(s): Minakawa S, Nakajima K, Aizu T, Nomura K, Kaimori M.
  • Journal Title: Clin Exp Dermatol 33 Pages: 808-810
  • Peer Reviewed
• [Journal Article] A de novo missense mutation in the keratin 13 gene in oral white sponge nevus. (2008)
  • Author(s): Nishizawa A, Nakajima K, Nakano H, Sawamura D, Satoh T, Yokozeki H.
  • Journal Title: Br J Dermatol 159 Pages: 974-975
  • Peer Reviewed
• [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinomaarising from recessive dystrophic epidermolysis bullosa. (2008)
  • Author(s): Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, Murai T, Tamai K, Sawamura D.
  • Journal Title: J Dermatol 35 Pages: 336-340
  • NAID: 10024297026
  • Peer Reviewed
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