Expression regulation of basement membrane proteins by transcription factor of epithelial to mesenchymal transition
| Project/Area Number |
21791055
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
NAKAJIMA Koji Hirosaki University, 大学院・医学研究科, 助教 (70374832)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 遺伝子 / シグナル伝達 / 発現制御 / 転写因子 |
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| Research Abstract |
Recent studies show that TGF-β is a key cytokine of EMT and zinc-finger transcription factor Snail also is a master transcription factor of EMT. Our group has been investigating on molecular mechanisms of expression regulation of basement membrane proteins and examining promoter analysis of BBAG1 and type VII collagen genes. The purpose of this study is to clarify how transcription factor Snail induced by TGF-β modulate expression of basement membrane proteins. The results showed that TGF-β induced expression of basement membrane proteins, resulting in suppression of EMT. Furthermore, transcription factor Snail played an important role in this phenomenon.
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Report
(3 results)
Research Products
(18 results)
