Development of a novel therapy targeting new intracellular receptors for the treatment of malignant melanoma
| Project/Area Number |
21791057
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
MATSUZAKI Yasushi Hirosaki University, 医学部附属病院, 講師 (50322946)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 皮膚腫瘍学 / RIG-I / メラノーマ / IFN |
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| Research Abstract |
I confirmed that cultured melanoma cells expressed RIG-I protein by IFN-βstimulation. Moreover, the levels of the IFN-β-induced RIG-I expression was dependent on the types of melanoma cell lines. It is necessary to identify intracellular signals via RIG-I in various melanoma cells.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma.2010
Author(s)
Rokunohe D, Nakano H, Akasaka E, Kimura K, Takiyoshi N, Nakajima K, Aizu T, Kaneko T, Matsuzaki Y, Tsuchida S, Sawamura D.
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Journal Title
J Dermatol Sci. 60(3)
Pages: 199-201
NAID
Related Report
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