Development of a novel therapy targeting new intracellular receptors for the treatment of malignant melanoma

• Project/Area Number: 21791057
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: MATSUZAKI Yasushi Hirosaki University, 医学部附属病院, 講師 (50322946)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 皮膚腫瘍学 / RIG-I / メラノーマ / IFN

Research Abstract

I confirmed that cultured melanoma cells expressed RIG-I protein by IFN-βstimulation. Moreover, the levels of the IFN-β-induced RIG-I expression was dependent on the types of melanoma cell lines. It is necessary to identify intracellular signals via RIG-I in various melanoma cells.

Research Products

• [Journal Article] Garlic-induced irritant contact dermatitis mimicking nail psoriasis. (2011)
  • Author(s): Takeuchi S, Matsuzaki Y, Ikenaga S, Nishikawa Y, Kimura K, Nakano H, Sawamura D.
  • Journal Title: J Dermatol 38(3) Pages: 280-282
  • NAID: 10029330800
• [Journal Article] Garlic-induced irritant contact dermatitis mimicking nail psoriasis (2011)
  • Author(s): Takeuchi S, et al
  • Journal Title: J Dermatol Volume: 38 Pages: 280-282
  • Peer Reviewed
• [Journal Article] Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma. (2010)
  • Author(s): Rokunohe D, Nakano H, Akasaka E, Kimura K, Takiyoshi N, Nakajima K, Aizu T, Kaneko T, Matsuzaki Y, Tsuchida S, Sawamura D.
  • Journal Title: J Dermatol Sci. 60(3) Pages: 199-201
  • NAID: 10027841189
• [Journal Article] Disseminated lupus vulgaris diagnosed more than 63 years after onset due to early misdiagnosis as a port-wine stain. (2010)
  • Author(s): Takeuchi S, Nakano H, Daiki R, Akasaka E, Nishizawa A, Matsuzaki Y, Sawamura D.
  • Journal Title: Clin Exp Dermatol 35
• [Journal Article] Overview of epidermolysis bullosa. (2010)
  • Author(s): Sawamura D, Nakano H, Matsuzaki Y.
  • Journal Title: J Dermatol 37 Pages: 214-219
  • NAID: 10027066027
• [Journal Article] Overview of epidermolysis bullosa (2010)
  • Author(s): Sawamura D, et al
  • Journal Title: J Dermatol Volume: 37 Pages: 214-219
  • Peer Reviewed
• [Journal Article] Disseminated lupus vulgaris diagnosed more than 63 years after onset due to early misdiagnosis as a port-wine stain (2010)
  • Author(s): Takeuchi S, et al
  • Journal Title: Clip Exp Dermatol Volume: 35
  • Peer Reviewed
• [Journal Article] Dermoscopy of eccrine poroma with calcification. (2009)
  • Author(s): Nishikawa Y, Kaneko T, Takiyoshi N, Aizu T, Nakajima K, Matsuzaki Y, Nakano H, Sawamura D.
  • Journal Title: J Dermatol Case Rep 3 Pages: 38-40
• [Journal Article] An eclipse in the subungual space : a diagnostic sign for a subungual epidermal cyst? (2009)
  • Author(s): Takiyoshi N, Nakano H, Matsuzaki Y, Aizu T, Kaneko T, Rokunohe D, Akasaka E, Jin K, Sawamura D, Ohara K.
  • Journal Title: Br J Dermatol 161 Pages: 962-963
• [Journal Article] Localized pagetoid reticulosis (Woringer-Kolopp disease) in early childhood. (2009)
  • Author(s): Matsuzaki Y, Kimura K, Nakano H, Hanada K, Sawamura D.
  • Journal Title: J Am Acad Dermatol 61 Pages: 120-123
• [Journal Article] CD20+ primary cutaneous T-cell lymphoma presenting as a solitary extensive plaque. (2009)
  • Author(s): Oshima H, Matsuzaki Y, Takeuchi S, Nakano H, Sawamura D.
  • Journal Title: Br J Dermatol 160 Pages: 894-896
• [Journal Article] 乾燥性皮膚に対する青森ヒバ抽出エキス配合スキンケア製剤の安全性および有用性に関する検討 (2009)
  • Author(s): 皆川智子、萩原千尋、西川陽平、松崎康司、中野創、澤村大輔、北山友佳子、金澤拓蔵、大見義紀
  • Journal Title: 西日本皮膚科 71(5) Pages: 512-516
  • NAID: 10026321576
• [Journal Article] CD20+ primary cutaneous T-cell lymphoma presenting as a solitary extensive plaque (2009)
  • Author(s): Hanae Oshima
  • Journal Title: Br J Dermatol 160 Pages: 894-896
  • Peer Reviewed
• [Journal Article] Localized pagetoid reticulosis(Woringer-Kolopp disease)in early childhood (2009)
  • Author(s): Yasushi Matsuzaki
  • Journal Title: J Am Acad Dermatol 61 Pages: 120-123
  • Peer Reviewed
• [Journal Article] An eclipse in the subungual space : a diagnostic sign for a subungual epidermal cyst? (2009)
  • Author(s): Noriko Takiyoshi
  • Journal Title: Br J Dermatol 161 Pages: 962-963
  • Peer Reviewed
• [Presentation] functional role of stimulator of interferon gene (STING) in antiviral response of human epidermal keratinocytes. (2010)
  • Author(s): Nishikawa Y, Matsuzaki Y, et al.
  • Organizer: European Society for Dermatological Research
  • Place of Presentation: Helsinki, Finland.
• [Presentation] A functional role of stimulator of interferon gene (STING) in antiviral response of human epidermal keratinocytes. (2010)
  • Author(s): Yohei Nishikawa
  • Organizer: European Society for Dermatological Research
  • Place of Presentation: Helsinki, FInland
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/-derma/index.html