Molecular Basis of Intolerance Against Hair Graying : Active Roles of PI3K and Stat3 Pathways

• Project/Area Number: 21791058
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Akita University
• Principal Investigator: KAWAMURA Nanami Akita University, 医学部, 助教 (70323152)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 白髪化 / PTEN / PI3K / STAT3

Research Abstract

In this grant program, we attempted to elucidate the biological roles of STAT3 and PI3Kγ during hair graying. The transgenic mouse studies showed that the genetic defect of both Stat3 and Pi3kγ genes enhance the radiosensitivity of malanocyte stem cells. These findings suggested that these molecules may play important roles in the maintenance of malanocyte stem cells.