The development of combination molecular target therapy of MITF, BRAF, and KIT for melanoma.

Research Project

Project/Area Number	21791069
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Shinshu University
Principal Investigator	KIDO Kenji Shinshu University, 医学部附属病院, 特任研究員 (00447765)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	皮膚腫瘍学 / 悪性黒色腫 / MITF / BRAF / KIT / sunitinib / RNA干渉 / 分子標的
Research Abstract	Tumor growth was suppressed by the inhibitor of MITF, BRAF, and KIT, individually. Unexpectedly, the suppression of tumor growth was not significant by using the three inhibitors of MITF, BRAF, and KIT together, compared to the inhibitor of MITF, BRAF, and KIT, individually.