Analysis about the regulatory function of B1-B cells
| Project/Area Number |
21791072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Research Collaborator |
TSUKAMOTO Yuko 滋賀医科大学, 皮膚科, 実験助手
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 免疫学 / 制御性機能 / B1-B細胞 / B10細胞 / 抑制性機能 |
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| Research Abstract |
Although intravenous immunoglobulins treatment is effective for various autoimmune diseases such as pemphigus, the exact mechanism of the therapy is unknown. Moreover, the efficacy is observed for limited periods in many cases. I evaluated the fluctuation of circulating IL-10 secreting B lymphocytes associated with intravenous immunoglobulins treatment. IL-10 secreting B cells were increased after the therapy in a case of pemphigus in which long-term clinical remission was achieved.
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Report
(4 results)
Research Products
(4 results)
