Analysis about the regulatory function of B1-B cells

Research Project

Project/Area Number	21791072
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Shiga University of Medical Science
Principal Investigator	FUJIMOTO Noriki 滋賀医科大学, 医学部, 講師 (50378460)
Research Collaborator	TSUKAMOTO Yuko 滋賀医科大学, 皮膚科, 実験助手
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	免疫学 / 制御性機能 / B1-B細胞 / B10細胞 / 抑制性機能
Research Abstract	Although intravenous immunoglobulins treatment is effective for various autoimmune diseases such as pemphigus, the exact mechanism of the therapy is unknown. Moreover, the efficacy is observed for limited periods in many cases. I evaluated the fluctuation of circulating IL-10 secreting B lymphocytes associated with intravenous immunoglobulins treatment. IL-10 secreting B cells were increased after the therapy in a case of pemphigus in which long-term clinical remission was achieved.

Report

(4 results)