| Project/Area Number |
21791074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
AKIHIKO Ikoma Kyoto University, 医学研究科, 非常勤講師 (10378614)
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| Research Collaborator |
福岡 美友紀 京都大学, 研究科, 大学院生
中東 恭子 京都大学, 研究科, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 痒み / アトピー性皮膚炎 / 痒み過敏 / ヒスタミン / ステロイド |
|---|
| Research Abstract |
Histamine- and serotonin-induced reactions such as itch in skin lesions of patients with atopic dermatitis, which are more intense than healthy skin, were dramatically improved by a 3-day treatment with steroid and tacrolimus ointments. Investigation of receptor expression revealed that receptor production was not likely to be influenced by treatment. This suggests that other factors such as the function of receptors rather than the number of receptors play a determinant role in itch sensitization of atopic dermatitis. This study has successfully demonstrated one of mechanisms for itch sensitization in atopic dermatitis that have not been investigated before.
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