The effects of statin on lymphangiogenesis in impaired wound healing

Research Project

Project/Area Number	21791086
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	ASAI Jun Kyoto Prefectural University of Medicine, 医学研究科, 助教 (50438222)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	マクロファージ / リンパ管 / 創傷治癒
Research Abstract	The present study showed topical application of simvastatin promoted lymphangiogenesis as well as angiogenesis during wound healing in genetically diabetic mice. These results suggested that both pre-existing lymphatic endothelial cells and infiltrating macrophages might contribute to newly organized vessels induced by simvastatin. In conclusion, a simple strategy of topically applied simvastatin may have significant therapeutic potential for enhanced wound healing in patients with impaired microcirculation such as occurs in diabetes.

Report

(3 results)