The role of PTEN in melanocyte stem cell maintainance in aged hair graying model mice

• Project/Area Number: 21791091
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Jichi Medical University
• Principal Investigator: NARITA Tae Jichi Medical University, 医学部, 助教 (10301061)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 色素細胞学 / 幹細胞

Research Abstract

To clarify the role of PTEN in melanocyte stem cell maintainance in hair graying, we studied PTEN role in bcl-2 null, or mitf mutant mice, which are known as hair graying model mice. We generated PTEN and bcl-2, or PTEN and mitf double mutant mice, and now studying their hair color change in natural aging.

Research Products

• [Journal Article] Induction of gene encoding FABP4 in Pten-null keratinocytes. (2009)
  • Author(s): Tsuda M, Inoue-Narita T, Suzuki A, Itami S, Blumenberg M, Manabe M.
  • Journal Title: FEBS Lett. 583(8) Pages: 1319-1322
• [Journal Article] Vasoactive intestinal peptide and inflammatory cytokines enhance vascular endothelial growth factor production from epidermal keratinocytes (2009)
  • Author(s): Kakurai M, Demitsu T, Umemoto N, Kobayashi Y, Inoue-Narita T, Fujita N, Ohtsuki M, Furukawa Y.
  • Journal Title: Br J Dermatol. 161(6) Pages: 1232-1238
• [Journal Article] A case of primary cutaneous natural killer/T-cell lymphoma, nasal type, with indolent clinical course : monoclonal expansion of Epstein-Barr virus genome correlating with the terminal aggressive behaviour. (2009)
  • Author(s): Watabe D, Kanno H, Inoue-Narita T, Onodera H, Izumida W, Kowata S, Sawai T, Akasaka T.
  • Journal Title: Br J Dermatol. 205-7. Pages: 205-207
• [Journal Article] SUPPRESSION OF SPONTANEOUS CARCINOGENESIS IN KERATINOCYTE-SPECIFIC PTEN-DEFICIENT MICE WITH SELECTIVE INHIBITION OF PI3K ISOFOR MS-Suppression of Spontaneous Carcinogenesis in Keratinocyte-Specific Pten-Deficient Mice with Selective Inhibition of PI3K Isoforms. (2009)
  • Author(s): Yamakawa T, Inoue-Narita T, Tsuda M, Hatakeyama S, Fujita S, Sasaki T, Suzuki A, Manabe M.
  • Journal Title: 秋田医学 36(1) Pages: 19-23
• [Journal Article] A case of primary cutaneous natural killer/T-cell lymphoma, nasal type, with indolent clinical course : monoclonal expansion of Epstein-Barr virus genome correlating with the terminal aggressive behaviour. (2009)
  • Author(s): Watabe D, Kanno H, Inoue-Narita T, Onodera H, Izumida W, Kowata S, Sawai T, Akasaka T.
  • Journal Title: Br J Dermatol. 205-7 Pages: 205-207
  • Peer Reviewed
• [Journal Article] SUPPRESSION OF SPONTANEOUS CARCINOGENESIS IN KERATINOCYTE-SPECIFIC PTEN-DEFICIENT MICE WITH SELECTIVE INHIBITION OF PI3K ISOFORMS -Suppression of Spontaneous Carcinogenesis in Keratinocyte-Specific Pten-Deficient Mice with Selective Inhibition of PI3K Isoforms (2009)
  • Author(s): Yamakawa T, Inoue-Narita T, Tsuda M, Hatakeyama S, Fujita S, Sasaki T, Suzuki A, Manabe M
  • Journal Title: 秋田医学 36(1) Pages: 19-23
  • Peer Reviewed
• [Presentation] PI3K経路の選択的阻害を基盤とする扁平上皮癌に対する分子標的療法の探索 (2010)
  • Author(s): 山川岳洋、真鍋求、成田多恵、鈴木聡
  • Organizer: 角化症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-31
• [Presentation] Induction of gene encoding FABP4 in Pten-Null keratinocyte (2009)
  • Author(s): Tsuda M, Inoue-Narita T, Suzuki A, Itami S, Blumenberg M, Manabe M
  • Organizer: 日本研究皮膚科学会 第34回年次学術大会
  • Place of Presentation: 福岡
• [Book] 皮膚症状から内科的疾患をみつけるためのエッセンス よく見て(じっくり考えようレジデントノート) (2010)
  • Author(s): 成田多恵
  • Total Pages: 150
  • Publisher: 羊土社
• [Book] やさしい皮膚病診療ガイド 皮膚科医の手の内を伝授!(小児に多い皮膚疾患 伝染性軟属腫) (2010)
  • Author(s): 成田多恵
  • Publisher: 南山堂
• [Book] 【皮膚で見つける全身疾患】びまん性色素沈着(POEMS症候群) (2010)
  • Author(s): 成田多恵、出光俊郎
  • Publisher: メディカルレビュ社
• [Book] やさしい皮膚病診療ガイド 皮膚科医の手の内を伝授!】小児に多い皮膚疾患 伝染性軟属腫 (2010)
  • Author(s): 成田多恵
  • Total Pages: 2
  • Publisher: 南山堂
• [Book] 皮膚症状から内科的疾患をみつけるためのエッセンスよく見て,レジデントノートじっくり考えよう (2010)
  • Author(s): 成田多恵
  • Total Pages: 150
  • Publisher: 羊土社